Publication Details

Category Text Publication
Reference Category Journals
DOI 10.14573/altex.1411011
Title (Primary) Integrated Testing Strategies (ITS) for safety assessment
Author Rovida, C.; Alépée, N.; Api, A.M.; Basketter, D.A.; Bois, F.Y.; Caloni, F.; Corsini, E.; Daneshian, M.; Eskes, C.; Ezendam, J.; Fuchs, H.; Hayden, P.; Hegele-Hartung, C.; Hoffmann, S.; Hubesch, B.; Jacobs, M.N.; Jaworska, J.; Kleensang, A.; Kleinstreuer, N.; Lalko, J.; Landsiedel, R.; Lebreux, F.; Luechtefeld, T.; Locatelli, M.; Mehling, A.; Natsch, A.; Pitchford, J.W.; Prater, D.; Prieto, P.; Schepky, A.; Schüürmann, G.; Smirnova, L.; Toole, C.; van Vliet, E.; Weisensee, D.; Hartung, T.
Journal ALTEX - Alternatives to Animal Experimentation
Year 2015
Department OEC
Volume 32
Issue 1
Page From 25
Page To 40
Language englisch
Keywords in vitro methods, testing strategy, Tox21c, skin sensitization, computational toxicology
UFZ wide themes RU3;
Abstract Integrated testing strategies (ITS), as opposed to a single definitive test or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the development of highly targeted tests and predictions, the need for combining pieces of evidence increases. The discussions that took place during this workshop, which brought together a group of experts coming from different related areas, illustrate the current state of the art of ITS, as well as promising developments and identifiable challenges. The case of skin sensitization was taken as an example to understand how possible ITS can be constructed, optimized and validated. This will require embracing and developing new concepts such as adverse outcome pathways (AOP), advanced statistical learning algorithms and machine learning, mechanistic validation and “Good ITS Practices”.
Persistent UFZ Identifier
Rovida, C., Alépée, N., Api, A.M., Basketter, D.A., Bois, F.Y., Caloni, F., Corsini, E., Daneshian, M., Eskes, C., Ezendam, J., Fuchs, H., Hayden, P., Hegele-Hartung, C., Hoffmann, S., Hubesch, B., Jacobs, M.N., Jaworska, J., Kleensang, A., Kleinstreuer, N., Lalko, J., Landsiedel, R., Lebreux, F., Luechtefeld, T., Locatelli, M., Mehling, A., Natsch, A., Pitchford, J.W., Prater, D., Prieto, P., Schepky, A., Schüürmann, G., Smirnova, L., Toole, C., van Vliet, E., Weisensee, D., Hartung, T. (2015):
Integrated Testing Strategies (ITS) for safety assessment
ALTEX-Altern. Anim. Exp. 32 (1), 25 - 40