Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1021/jp509348a |
| Document | author version |
| Title (Primary) | Prediction of phospholipid−water partition coefficients of ionic organic chemicals using the mechanistic model COSMOmic |
| Author | Bittermann, K.; Spycher, S.; Endo, S.; Pohler, L.; Huniar, U.; Goss, K.-U.; Klamt, A. |
| Source Titel | Journal of Physical Chemistry B |
| Year | 2014 |
| Department | AUC |
| Volume | 118 |
| Issue | 51 |
| Page From | 14833 |
| Page To | 14842 |
| Language | englisch |
| Keywords | partition coefficients; lipid membranes; ions; membrane dipole potential; COSMO-RS |
| UFZ wide themes | RU3; |
| Abstract | The partition coefficient of chemicals from water to phospholipid membrane, Klipw, is of central importance for various fields. For neutral organic molecules, log Klipw correlates with the log of bulk solvent–water partition coefficients such as the octanol–water partition coefficient. However, this is not the case for charged compounds, for which a mechanistic modeling approach is highly necessary. In this work, we extend the model COSMOmic, which adapts the COSMO-RS theory for anisotropic phases and has been shown to reliably predict Klipw for neutral compounds, to the use of ionic compounds. To make the COSMOmic model applicable for ionic solutes, we implemented the internal membrane dipole potential in COSMOmic. We empirically optimized the potential with experimental Klipw data of 161 neutral and 75 ionic compounds, yielding potential shapes that agree well with experimentally determined potentials from the literature. This model refinement has no negative effect on the prediction accuracy of neutral compounds (root-mean-square error, RMSE = 0.62 log units), while it highly improves the prediction of ions (RMSE = 0.70 log units). The refined COSMOmic is, to our knowledge, the first mechanistic model that predicts Klipw of both ionic and neutral species with accuracies better than 1 log unit. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=15718 |
| Bittermann, K., Spycher, S., Endo, S., Pohler, L., Huniar, U., Goss, K.-U., Klamt, A. (2014): Prediction of phospholipid−water partition coefficients of ionic organic chemicals using the mechanistic model COSMOmic J. Phys. Chem. B 118 (51), 14833 - 14842 10.1021/jp509348a |
|