Publication Details

Reference Category Journals
DOI / URL link
Title (Primary) Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)
Author Lombardo, A.; Roncaglioni, A.; Benfenati, E.; Nendza, M.; Segner, H.; Jeram, S.; Pauné, E.; Schüürmann, G.;
Journal Environmental Research
Year 2014
Department OEC;
Volume 135
Language englisch;
POF III (all) T41;
Keywords ITS; REACH; Aquatic toxicity; Alternative methods; Hazard assessment
UFZ wide themes RU3;
Abstract To satisfy REACH requirements a high number of data on chemical of interest should be supplied to the European Chemicals Agency. To organize the various kinds of information and help the registrants to choose the best strategy to obtain the needed information limiting at the minimum the use of animal testing, integrated testing strategies (ITSs) schemes can be used. The present work deals with regulatory data requirements for assessing the hazards of chemicals to the aquatic pelagic environment. We present an ITS scheme for organizing and using the complex existing data available for aquatic toxicity assessment. An ITS to optimize the choice of the correct prediction strategy for aquatic pelagic toxicity is described. All existing information (like physico-chemical information), and all the alternative methods (like in silico, in vitro or the acute-to-chronic ratio) are considered. Moreover the weight of evidence approach to combine the available data is included
ID 15340
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=15340
Lombardo, A., Roncaglioni, A., Benfenati, E., Nendza, M., Segner, H., Jeram, S., Pauné, E., Schüürmann, G. (2014):
Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)
Environ. Res. 135 , 156 - 164