Publication Details

Reference Category Journals
DOI / URL link
Title (Primary) Nonextractable residue formation of sulfonamide antimicrobials: New insights from soil incubation experiments
Author Gulkowska, A.; Thalmann, B.; Hollender, J.; Krauss, M.;
Journal Chemosphere
Year 2014
Department WANA;
Volume 107
Language englisch;
POF III (all) T32;
Keywords Sulfonamide antimicrobials; Nonextractable residues; Nucleophilic addition; Sequential extraction
UFZ wide themes RU2;
Abstract Soil incubation experiments using 14C-labelled sulfamethazine were carried out to assess the factors governing its nonextractable residue (NER) formation via nucleophilic addition reactions. Circumstantial evidence on possible mechanisms of NER formation was derived from a selective manipulation of soil samples. The amount of quinones in soil available for nucleophilic addition was a limiting factor as indicated by (i) an (initial) increase of NER formation by adding quinone precursors or enhancing their formation by manganese oxide addition and (ii) a decrease of NER formation by limiting the formation of quinones under anaerobic conditions. A slow NER formation with time under aerobic conditions is likely caused by covalent bonding as well, because no slow NER formation phase was observed under anaerobic conditions.
ID 14875
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14875
Gulkowska, A., Thalmann, B., Hollender, J., Krauss, M. (2014):
Nonextractable residue formation of sulfonamide antimicrobials: New insights from soil incubation experiments
Chemosphere 107 , 366 - 372