Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| Title (Primary) | Non-animal approaches for the predictive assessment of the aquatic toxicity of organic compounds |
| Author | Schüürmann, G. |
| Source Titel | Abstracts of Papers of the American Chemical Society |
| Year | 2013 |
| Department | OEC |
| Volume | 246 |
| Page From | 125-ENVR |
| Language | englisch |
| UFZ wide themes | ru3 |
| Abstract | Through the implementation of the European Directive REACH in 2007, alternative methods have gained importance as non-animal tools for the toxicological assessment of chemical substances. In this context, the 3R principle of reducing, refining and replacing animal testing has seen a paradigm shift, moving from 1:1 replacements to integrated testing strategies (ITS) that exploit the combined information from several non-animal methods (1:n replacement). In the presentation, non-test and test methods as major ITS components are outlined. The focus is on models to predict aquatic toxicity, employing quantitative read-across,1 structural alerts, and consensus modelling to compensate for individual method drawbacks. The discussion includes chemoassays to sense electrophilic reactivity,2 bioassays for deriving structural alerts,3 computational chemistry for predicting reactive toxicity4-5 as well as P450-catalysed biotransformation,6 and the issue of chemoavailability.7 |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14500 |
| Schüürmann, G. (2013): Non-animal approaches for the predictive assessment of the aquatic toxicity of organic compounds Abstr. Paper Am. Chem. Soc. 246 , 125-ENVR |
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