This article gives insights into an inter- and transdisciplinary research approach designed to enhance the planning of climate change adaptation responses at urban-regional level. What makes interdisciplinary approaches to adaptation action unique is its ability to unravel the complexity of climate change and the interwoven processes it entails. It is the planning aspect here that makes stakeholder involvement crucial. Hence in contemporary climate change research the science-policy interface takes centre stage, generating response capacity and exchanging ‘usable’ information with decision-makers within the framework of a transdisciplinary approach. Climate action plans and climate adaptation strategies, for example, have the potential to unite sectors and levels of decision-making around an integrated planning approach. This article discusses the challenges and constraints of the inter- and transdisciplinary research approach developed for a Metropolitan Region of Santiago de Chile (MRS).