New methods and technologies for energy storage are required to make a transition to renewable energy sources; in Germany this transition is termed “Energiewende”. Subsurface georeservoirs, such as salt caverns for hydrogen, compressed air, and methane storage or porous formations for heat and gas storage, offer the possibility of hosting large amounts of energy. When employing these geological storage facilities, an adequate system and process understanding is essential in order to characterize and to predict the complex and interacting effects on other types of subsurface use and on protected entities. In order to make optimal use of georeservoirs, a comprehensive use planning of the subsurface is required that allocates specific uses to appropriate subsurface locations. This paper presents a generic methodology on how subsurface use planning can be conducted and how its scientific basis can be developed. Although synthetic, realistic scenarios for the use of the geological underground for energy storage are parameterized and numerically simulated, accounting for other kinds of subsurface use already in place. From these scenario analyses, the imposed coupled hydraulic, thermal, mechanical and chemical processes, as well as mutual effects and influences on protected entities are assessed and generalized. Based on these, a first methodology for large-scale planning of the geological subsurface considering different surface and subsurface usage scenarios may also be derived.