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Title (Primary) Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma
Author MacIntyre, E.A.; Carlsten, C.; MacNutt, M.; Fuertes, E.; Melen, E.; Tiesler, C.M.T.; Gehring, U.; Kraemer, U.; Kluemper, C.; Kerkhof, M.; Chan-Yeung, M.; Kozyrskyj, A.L.; Berdel, D.; Bauer, C.P.; Herbarth, O.; Bauer, M.; Schaaf, B.; Koletzko, S.; Pershagen, G.; Brunekreef, B.; Heinrich, J.; Brauer, M.;
Journal European Journal of Epidemiology
Year 2013
Department IMMU;
Volume 28
Issue 7
Language englisch;
POF III (all) F11;
Supplements https://static-content.springer.com/esm/art%3A10.1007%2Fs10654-013-9828-5/MediaObjects/10654_2013_9828_MOESM1_ESM.docx
Keywords Air pollution; GSTP1; TNF; Asthma; Wheeze; Gene-environment
UFZ wide themes ru3
Abstract Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11–17 %) and homozygosity for the minor allele was 1 % (0–2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40–48 %) and homozygosity for the minor allele, 12 % (10–12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25–32 %) and homozygosity for the minor allele, 3 % (1–3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease.
ID 14042
Persistent UFZ Identifier http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14042
MacIntyre, E.A., Carlsten, C., MacNutt, M., Fuertes, E., Melen, E., Tiesler, C.M.T., Gehring, U., Kraemer, U., Kluemper, C., Kerkhof, M., Chan-Yeung, M., Kozyrskyj, A.L., Berdel, D., Bauer, C.P., Herbarth, O., Bauer, M., Schaaf, B., Koletzko, S., Pershagen, G., Brunekreef, B., Heinrich, J., Brauer, M. (2013):
Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma
Eur. J. Epidemiol. 28 (7), 597 - 606