Publication Details

Category Text Publication
Reference Category Book chapters
DOI 10.1061/9780784412992.254
Title (Primary) Enhanced poromechanical properties of tissue engineered cartilage via swelling induced collagen remodelling
Title (Secondary) Proceedings of the 5th Biot Conference on Poromechanics, Vienna, Austria, July 10-12, 2013
Author Nagel, T.; Kolditz, O. ORCID logo ; Kelly, D.J.
Year 2013
Department ENVINF
Page From 2158
Page To 2165
Language englisch
UFZ wide themes RU5;
Abstract

Mechanical loading and changes in culture media are both applied in bioreactors to improve the functionality of engineered cartilage tissue. The mechanical properties of articular cartilage are in part determined by its collagen architecture. It was previously shown that mechanical loading can alter structural characteristics of the collagen network. In this study, the influence of culture medium osmolarity and proteoglycan depletion on the collagen network in free swelling hydrogels was investigated with a remodelling algorithm. The driving force for remodelling was the balance between osmotic swelling pressures and tensile stresses in the collagen network as well as the hydrogel scaffold. A finite deformation biphasic model was used to describe the hydrogel and the tissue engineered cartilage. It was demonstrated that proteoglycan digestion at discrete time points during culture and culture in a hypertonic medium can improve the functionality of the collagen network. The positive changes manifested themselves as elevated stiffness values, lower permeabilities and an overall more compact tissue.

Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14032
Nagel, T., Kolditz, O., Kelly, D.J. (2013):
Enhanced poromechanical properties of tissue engineered cartilage via swelling induced collagen remodelling
Proceedings of the 5th Biot Conference on Poromechanics, Vienna, Austria, July 10-12, 2013
American Society of Civil Engineers (ASCE), p. 2158 - 2165 10.1061/9780784412992.254