Current research into CO2 capture and storage is dominated by improving the CO2 storage capacity. In this context, risk related to CO2 leakage is an important issue which may cause environmental problems, particularly when freshwater resources nearby are intruded by the CO2 plume. In this work, the leakage into a multi-layered fractured saline aquifer is modelled with a numerical model regarding its pressure build-up process. The investigation is performed with the non-isothermal compositional fluid flow module implemented by authors in the OpenGeoSys (OGS) software for geotechnical applications.