Against the background of a continuing biodiversity loss there is a strong need to improve the interfaces between science and policy. Many approaches for such interfaces exist, the most recent being the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES). A less prominent approach to interface science with policy consists of research projects directly linking with decision makers. Here we present insights and recommendations on how to do this successfully, highlighting among others the role of facilitating mutual learning and enhancing interface expertise in institutions.