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Title (Primary) Association of atopic and non-atopic asthma with emotional symptoms in school children
Author Kohlboeck, G.; Koletzko, S.; Bauer, C.-P.; von Berg, A.; Berdel, D.; Krämer, U.; Schaaf, B.; Lehmann, I.; Herbarth, O.; Heinrich, J.;
Journal Pediatric Allergy and Immunology
Year 2013
Department IMMU;
Volume 24
Issue 3
Language englisch;
POF III (all) F11; T42;
Keywords asthma;atopy;allergy;behavior problems;epidemiology;depression;comorbidity;affective disorders
UFZ wide themes RU3;
Abstract Objective: To date, there is conflicting evidence whether the association between
asthma and depression depends on the atopic or non-atopic asthma phenotype. This
study investigates associations between emotional symptoms and atopic and nonatopic
asthma in school-aged children.
Methods: Cross-sectional data on asthma and allergic diseases at the 10-year followup
of two birth cohorts were collected by parent-reported physician diagnoses. Specific
IgE levels including most common inhalant allergens (SX1) and food allergens (FX5)
were measured by RAST-CAP FEIA. Atopic asthma was defined as asthma ever and
positive specific IgE test, non-atopic asthma as asthma ever and no IgE sensitization.
Emotional symptoms were assessed by parent-reported strength and difficulty
questionnaire. Logistic regression modeling were applied to determine likelihood of
emotional symptoms in children with atopic and non-atopic asthma controlling for
socio-demographic factors, body mass index, atopic eczema, allergic rhinitis, and
pubertal development.
Results: Non-atopic asthma was associated with about 3-fold higher likelihood of
emotional symptoms compared to children with no asthma (ORadj = 2.90,
CI95% = 1.46–5.73). Atopic asthma was not associated with emotional symptoms
(ORadj = 1.35, CI95% = 0.81–2.26).
Conclusions: Atopic and non-atopic asthma in children might have different etiologies,
whereas for non-atopic asthma, emotional symptoms are relevant, this is not the case
in atopic asthma. The relationship between the non-atopic asthma phenotype and
emotional symptoms might be dependent on gender.
ID 13686
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13686
Kohlboeck, G., Koletzko, S., Bauer, C.-P., von Berg, A., Berdel, D., Krämer, U., Schaaf, B., Lehmann, I., Herbarth, O., Heinrich, J. (2013):
Association of atopic and non-atopic asthma with emotional symptoms in school children
Pediatr. Allergy Immunol. 24 (3), 230 - 236