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Title (Primary) Most oxidative stress response in water samples comes from unknown chemicals: the need for effect-based water quality trigger values
Author Escher, B.I.; van Daele, C.; Dutt, M.; Tang, J.Y.M.; Altenburger, R.;
Journal Environmental Science & Technology
Year 2013
Department BIOTOX;
Volume 47
Issue 13
Language englisch;
POF III (all) T42;
UFZ wide themes RU3;
Abstract The induction of adaptive stress response pathways is an early and sensitive indicator of the presence of chemical and non-chemical stressors in cells. An important stress response is the Nrf-2 mediated oxidative stress response pathway where electrophilic chemicals or chemicals that cause the formation of reactive oxygen species initiate the production of antioxidants and metabolic detoxification enzymes. The AREc32 cell line is sensitive to chemicals inducing oxidative stress and has been previously applied for water quality monitoring of organic micropollutants and disinfection by-products. Here we propose an algorithm for the derivation of effect-based water quality trigger values for this endpoint that is based on the combined effects of mixtures of regulated chemicals. Mixture experiments agreed with predictions by the mixture toxicity concept of concentration addition. The responses in the AREc32 and the concentrations of 269 individual chemicals were quantified in nine environmental samples, ranging from treated effluent, recycled water, stormwater to drinking water. The effects of the detected chemicals could explain less than 0.1% of the observed induction of the oxidative stress response in the sample, affirming the need to use effect-based trigger values that account for all chemicals present.
ID 13498
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13498
Escher, B.I., van Daele, C., Dutt, M., Tang, J.Y.M., Altenburger, R. (2013):
Most oxidative stress response in water samples comes from unknown chemicals: the need for effect-based water quality trigger values
Environ. Sci. Technol. 47 (13), 7002 - 7011