Publication Details

Reference Category Book chapters
DOI / URL link
Title (Primary) Evaluation of health risks of nanoparticles - a contribution to a sustainable development of nanotechnology
Title (Secondary) Nanocomposite materials
Author Potthoff, A.; Meißner, T.; Richter, V.; Busch, W.; Kühnel, D.; Bastian, S.; Iwe, M.; Springer, A.
Publisher Kny, E.
Journal Solid State Phenomena
Year 2009
Department BIOTOX
Volume 151
Page From 183
Page To 189
Language englisch
Abstract

The increasing use of nanoparticles makes it necessary to check up possible toxicological risks of this new materials class. In this paper we describe on two nanopowders (tungsten carbide, titanium nitride) which methods and parameters of a chemical-physical characterization are needed in forefront of toxicological experiments. This includes investigation on the powder itself as well as on particles suspended in water and physiological media, respectively. The most important result is that nanoparticles agglomerate in serum-free medium within minutes, whereas in the present of serum an agglomeration is inhibited. Hence, we have physiological suspensions with well-distributed stabilized particles which allow performing toxicological testing under reproducible conditions. Furthermore we could prove that tungsten carbide particles were taken up into cells, but no acute toxicity was found determined by means of in vitro viability tests with different cells.

Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12799
Potthoff, A., Meißner, T., Richter, V., Busch, W., Kühnel, D., Bastian, S., Iwe, M., Springer, A. (2009):
Evaluation of health risks of nanoparticles - a contribution to a sustainable development of nanotechnology
In: Kny, E. (ed.)
Nanocomposite materials
Solid State Phenomena 151
Trans Tech Publications, Durnten-Zurich, p. 183 - 189