Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1080/10256016.2011.556725 |
| Title (Primary) | Large deuterium isotope effects and their use: a historical review |
| Author | Krumbiegel, P. |
| Source Titel | Isotopes in Environmental and Health Studies |
| Year | 2011 |
| Department | HDG |
| Volume | 47 |
| Issue | 1 |
| Page From | 1 |
| Page To | 17 |
| Language | englisch |
| Keywords | hydrogen-2; isotope application; isotope effects; men; oils; pharmaceuticals; review; safety; stabilisation; technical use |
| Abstract | Isotope effects are differences in the properties of the isotopes of an element resulting in different reaction rates of a corresponding compound, in equilibrium constants and in the spectra. Shortly after the discovery of stable isotopes of hydrogen, oxygen, and carbon, Jacob Bigeleisen formulated a theory of isotope effects and calculated possible maximum values. Large isotope effects of 2H (deuterium) against 1H (protium) were seen to possibly influence interpretations of reaction mechanisms if corresponding labelling is used. Much work was invested to ensure the safety of deuterium use in men in spite of the large isotope effect. On the other hand, large deuterium isotope effects gave rise to several practical applications. Examples are the enhancement of the stability of some technical products against oxidative and against hydrolytic degradation (oils, pharmaceuticals) as well as alterations of the detoxification metabolism of pharmaceuticals in vivo. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=12101 |
| Krumbiegel, P. (2011): Large deuterium isotope effects and their use: a historical review Isot. Environ. Health Stud. 47 (1), 1 - 17 10.1080/10256016.2011.556725 |
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