|DOI / URL||link|
|Title (Primary)||The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation|
|Author||Callaghan, A.V.; Morris, B.E.L.; Pereira, I.A.C.; McInerney, M.J.; Austin, R.N.; Groves, J.T.; Kukor, J.J.; Suflita, J.M.; Young, L.Y.; Zylstra, G.J.; Wawrik, B.;|
Desulfatibacillum alkenivorans AK-01 serves as a model organism for anaerobic alkane biodegradation because of its distinctive biochemistry and metabolic versatility. The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved in alkane metabolism including substrate activation, CoA ligation, carbon-skeleton rearrangement and decarboxylation. Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Pathways involved in the oxidation of alkanes, alcohols, organic acids and n-saturated fatty acids coupled to sulfate reduction and the ability to grow chemolithoautotrophically were predicted. A complement of genes for motility and oxygen detoxification suggests that D. alkenivorans may be physiologically adapted to a wide range of environmental conditions. The D. alkenivorans genome serves as a platform for further study of anaerobic, hydrocarbon-oxidizing microorganisms and their roles in bioremediation, energy recovery and global carbon cycling.
|Persistent UFZ Identifier||https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=11365|
|Callaghan, A.V., Morris, B.E.L., Pereira, I.A.C., McInerney, M.J., Austin, R.N., Groves, J.T., Kukor, J.J., Suflita, J.M., Young, L.Y., Zylstra, G.J., Wawrik, B. (2012):
The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation
Environ. Microbiol. 14 (1), 101 - 113