Publication Details |
Category | Text Publication |
Reference Category | Journals |
DOI | 10.1111/j.1462-2920.2011.02516.x |
Document | Shareable Link |
Title (Primary) | The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation |
Author | Callaghan, A.V.; Morris, B.E.L.; Pereira, I.A.C.; McInerney, M.J.; Austin, R.N.; Groves, J.T.; Kukor, J.J.; Suflita, J.M.; Young, L.Y.; Zylstra, G.J.; Wawrik, B. |
Source Titel | Environmental Microbiology |
Year | 2012 |
Department | ISOBIO |
Volume | 14 |
Issue | 1 |
Page From | 101 |
Page To | 113 |
Language | englisch |
Abstract |
Desulfatibacillum alkenivorans AK-01 serves as a model organism for anaerobic alkane biodegradation because of its distinctive biochemistry and metabolic versatility. The D. alkenivorans genome provides a blueprint for understanding the genetic systems involved in alkane metabolism including substrate activation, CoA ligation, carbon-skeleton rearrangement and decarboxylation. Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Pathways involved in the oxidation of alkanes, alcohols, organic acids and n-saturated fatty acids coupled to sulfate reduction and the ability to grow chemolithoautotrophically were predicted. A complement of genes for motility and oxygen detoxification suggests that D. alkenivorans may be physiologically adapted to a wide range of environmental conditions. The D. alkenivorans genome serves as a platform for further study of anaerobic, hydrocarbon-oxidizing microorganisms and their roles in bioremediation, energy recovery and global carbon cycling. |
Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=11365 |
Callaghan, A.V., Morris, B.E.L., Pereira, I.A.C., McInerney, M.J., Austin, R.N., Groves, J.T., Kukor, J.J., Suflita, J.M., Young, L.Y., Zylstra, G.J., Wawrik, B. (2012): The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation Environ. Microbiol. 14 (1), 101 - 113 10.1111/j.1462-2920.2011.02516.x |