|DOI / URL||link|
|Title (Primary)||Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life|
|Author||Rzehak, P.; Thijs, C.; Standl, M.; Mommers, M.; Glaeser, C.; Jansen, E.; Klopp, N.; Koppelman, G.H.; Singmann, P.; Postma, D.S.; Sausenthaler, S.; Dagnelie, P.C.; van den Brandt, P.A.; Koletzko, B.; Heinrich, J.; Wichmann, H.-E.; Schoetzau, A.; Franke, K.; Laubereau, B.; Schaaf, B.; Borte, M.; Schulz, R.; Sierig, G.; Sack, U.; Emmrich, F.; von Berg, A.; Bollrath, C.; Herbarth, O.; Diez, U.; Lehmann, I.; Herberth, G.;|
Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied.
Methods and Principal Findings
Data of two population-based-birth-cohorts in the Netherlands and Germany (KOALA, LISA) were pooled (n = 879) and analyzed by (logistic) regression regarding the mutual influence of single-nucleotide-polymorphisms (SNPs) in the FADS-gene-cluster (rs174545, rs174546, rs174556, rs174561, rs3834458), on polyunsaturated fatty acids (PUFA) in blood and parent-reported eczema until the age of 2 years. All SNPs were highly significantly associated with all PUFAs except for alpha-linolenic-acid and eicosapentaenoic-acid, also after correction for multiple-testing. All tested SNPs showed associations with eczema in the LISA-study, but not in the KOALA-study. None of the PUFAs was significantly associated with eczema neither in the pooled nor in the analyses stratified by study-cohort.
Conclusions and Significance
PUFA-composition in young children's blood is under strong control of the FADS-gene-cluster. Inconsistent results were found for a link between these genetic-variants with eczema. PUFA in blood was not associated with eczema. Thus the hypothesis of an inflammatory-link between PUFA and eczema by the metabolic-pathway of LC-PUFAs as precursors for inflammatory prostaglandins and leukotrienes could not be confirmed by these data.
|Persistent UFZ Identifier||http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=11342|
|Rzehak, P., Thijs, C., Standl, M., Mommers, M., Glaeser, C., Jansen, E., Klopp, N., Koppelman, G.H., Singmann, P., Postma, D.S., Sausenthaler, S., Dagnelie, P.C., van den Brandt, P.A., Koletzko, B., Heinrich, J., Wichmann, H.-E., Schoetzau, A., Franke, K., Laubereau, B., Schaaf, B., Borte, M., Schulz, R., Sierig, G., Sack, U., Emmrich, F., von Berg, A., Bollrath, C., Herbarth, O., Diez, U., Lehmann, I., Herberth, G. (2010):
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life
PLoS One 5 (10), e13261