Regularly occurring flood events do have a history in Santiago de Chile, the capital city of Chile and study area for this research. The analysis of flood events, the resulting damage and its causes are crucial prerequisites for the development of risk prevention measures. The goal of this research is to empirically investigate the vulnerability towards floods in Santiago de Chile as one component of flood risk. The analysis and assessment of vulnerability is based on the application of a multi-scale (individual, household, municipal level) set of indicators and the use of a broad range of data. The case-specific set of indicators developed in this study shows the relevant variables and their interrelations influencing the flood vulnerability in the study area. It provides a decision support tool for stakeholders and allows for monitoring and evaluating changes over time. The paper outlines how GIS, census, and remote sensing data as well as household surveys and expert interviews are used as an information base for the derivation of a vulnerability map for two municipalities located in the eastern part of Santiago de Chile. The generation of vulnerability maps representing the two different perspectives of local decision makers (experts) and affected households is exemplified and discussed using the developed methodology.