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Title (Primary) Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection
Author Kleinschek, M.A.; Müller, U.; Schütze, N.; Sabat, N.; Straubinger, R.K.; Blumenschein, W.M.; McClanahan, T.; Kastelein, R.A.; Alber, G.;
Journal International Immunology
Year 2010
Department IMMU;
Volume 22
Issue 2
Language englisch;
Keywords Cryptococcus; cytokine; gene-deficient mice; infection, Th17
Abstract IL-23 is a key cytokine in promotion of chronic inflammation. Here, we address if its pro-inflammatory potential can be harnessed to protect against chronic cryptococcosis. Mice were infected with Cryptococcus neoformans and treated with recombinant IL-23. Administration of IL-23 led to prolonged survival and reduced fungal burden but was inferior to IL-12 treatment. Independent of endogenous IL-23/IL-12, IL-23 treatment induced an altered cytokine profile accompanied by marked changes in composition of the inflammatory infiltrate characterized by T cell and dendritic cell recruitment. Although IL-23 induced hallmarks of the Th17 pathway, also non-T cells produced IL-17A and IL-22. IL-23 treatment of T-cell-deficient mice resulted in increased IL-17A and IL-22 production and modulation of the cellular response at the site of infection with elevated expression of CD86 on macrophages. Our data show that IL-23 treatment induces innate and adaptive tissue inflammation with limited impact on resistance to chronic cryptococcosis.
ID 10158
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=10158
Kleinschek, M.A., Müller, U., Schütze, N., Sabat, N., Straubinger, R.K., Blumenschein, W.M., McClanahan, T., Kastelein, R.A., Alber, G. (2010):
Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection
Int. Immunol. 22 (2), 81 - 90