Publication Details |
| Category | Text Publication |
| Reference Category | Book chapters |
| DOI | 10.1007/978-3-540-77587-4_112 |
| Title (Primary) | Cis-trans isomerase of unsaturated fatty acids: an immediate bacterial adaptive mechanism to cope with emerging membrane perturbation caused by toxic hydrocarbons |
| Title (Secondary) | Microbial utilization of hydrocarbons, oils and lipids |
| Author | Heipieper, H.J.
; Fischer, J.; Meinhardt, F. |
| Publisher | Timmis, K.N.; McGenity, T.; van den Meer, J.R.; de Lorenzo, V. |
| Source Titel | Handbook of Hydrocarbon and Lipid Microbiology |
| Year | 2010 |
| Department | UBT |
| Volume | Vol. 2, Part 9 |
| Page From | 1605 |
| Page To | 1614 |
| Language | englisch |
| UFZ inventory | Leipzig, Bibliothek, Hauptlesesaal, 00358095, 09-1341 DK: 579.222.5 Han |
| Abstract | A rather efficient solvent adaptation mechanism enabling several gram-negative bacteria to tolerate and grow in the presence of membrane-disturbing compounds is the isomerization of cis- to trans-unsaturated membrane fatty acids. The degree of isomerization obviously depends on the toxicity and the concentration of membrane-affecting agents. Synthesis of trans-fatty acids comes about by direct isomerization of the respective cis-configuration of the double bond without shifting the position. The purpose of the conversion of the cis-configuration to trans is apparently the rapid adaptation of the membrane fluidity to rising temperature or the presence of toxic organic hydrocarbons. The cis-trans-isomerase (Cti) is a constitutively expressed periplasmic enzyme that - to exert its action - necessitates neither ATP nor other cofactors, and consistently, is independent of de novo synthesis of lipids. A heme-binding site typical of cytochrome c-type proteins is present in the predicted Cti polypeptide indicating a reaction mechanism that renounces temporary saturation of the double bond. Due to its direct correlation with toxicity, cis-trans-isomerization is a potential biomarker for recording solvent stress or changes of other environmental conditions. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=10070 |
| Heipieper, H.J., Fischer, J., Meinhardt, F. (2010): Cis-trans isomerase of unsaturated fatty acids: an immediate bacterial adaptive mechanism to cope with emerging membrane perturbation caused by toxic hydrocarbons In: Timmis, K.N., McGenity, T., van den Meer, J.R., de Lorenzo, V. (eds.) Microbial utilization of hydrocarbons, oils and lipids Handbook of Hydrocarbon and Lipid Microbiology Vol. 2, Part 9 Springer International Publishing, Cham, p. 1605 - 1614 10.1007/978-3-540-77587-4_112 |
|