Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3109/00016480903168066
Title (Primary) Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea
Author Heinrich, U.-R.; Selivanova, O.; Schmidtmann, I.; Feltens, R.; Brieger, J.; Mann, W.J.
Source Titel Acta Oto-Laryngologica
Year 2010
Department PROTEOM
Volume 130
Issue 3
Page From 358
Page To 365
Language englisch
Keywords arachidonic acid; organ of Corti; stria vascularis; spiral ganglion; immunohistochemistry; hearing
Abstract Conclusion. Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity. Objectives. The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contributes to noise-induced hearing loss. The aim of this study was to gain further information about noise-dependent changes in AA metabolism in the mammalian cochlea. Methods. In this prospective animal study, 10 male guinea pigs were exposed to tone bursts for 1 h at 70 dB sound pressure level (SPL) (n=5) or 90 dB SPL (n=5). Five animals were used as controls. Alterations in cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression were determined by quantitative immunohistochemical analysis in 11 cochlear regions. Results. COX-1 expression was decreased after both 70 dB SPL and 90 dB SPL exposure in most cell types of the organ of Corti and increased in the nerve fibers of the osseous spiral lamina. 5-LO was lowered after 90 dB SPL exposure, preferentially in the third cochlear turn in the organ of Corti, in the first and second turn in spiral ganglion cells, and in all turns in the stria vascularis.
Persistent UFZ Identifier
Heinrich, U.-R., Selivanova, O., Schmidtmann, I., Feltens, R., Brieger, J., Mann, W.J. (2010):
Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea
Acta Oto-Laryngol. 130 (3), 358 - 365 10.3109/00016480903168066