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15722 Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barceló, D., Seiler, T.-B., Brion, F., Busch, W., Chipman, K., López de Alda, M., De Aragão Umbuzeiro, G., Escher, B.I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jäger, F., Jahnke, A., Kortenkamp, A., Krauss, M., Lemkine, G.F., Munthe, J., Neumann, S., Schymanski, E.L., Scrimshaw, M., Segner, H., Slobodnik, J., Smedes, F., Kughathas, S., Teodorovic, I., Tindall, A.J., Tollefsen, K.E., Walz, K.-H., Williams, T.D., van den Brink, P.J., van Gils, J., Vrana, B., Zhang, X., Brack, W. (2015):
Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management
Sci. Total Environ. 512-513 , 540 - 551
full text (doi)
19970 Altenburger, R., Scholze, M., Busch, W., Escher, B.I., Jakobs, G., Krauss, M., Krüger, J., Neale, P.A., Ait-Aissa, S., Almeida, A.C., Seiler, T.-B., Brion, F., Hilscherová, K., Hollert, H., Novák, J., Schlichting, R., Serra, H., Shao, Y., Tindall, A., Tolefsen, K.-E., Umbuzeiro, G., Williams, T.D., Kortenkamp, A. (2018):
Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays
Environ. Int. 114 , 95 - 106
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22607 Backhaus, T., Brack, W., van den Brink, P.J., Deutschmann, B., Hollert, H., Posthuma, L., Segner, H., Seiler, T.-B., Teodorovic, I., Focks, A. (2019):
Assessing the ecological impact of chemical pollution on aquatic ecosystems requires the systematic exploration and evaluation of four lines of evidence
Environ. Sci. Eur. 31 , art. 98
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21513 Brack, W., Ait-Aissa, S., Backhaus, T., Dulio, V., Escher, B.I., Faust, M., Hilscherova, K., Hollender, J., Hollert, H., Müller, C., Munthe, J., Posthuma, L., Seiler, T.-B., Slobodnik, J., Teodorovic, I., Tindall, A.J., De Aragão Umbuzeiro, G., Zhang, X., Altenburger, R. (2019):
Effect‑based methods are key. The European Collaborative Project SOLUTIONS recommends integrating effect‑based methods for diagnosis and monitoring of water quality
Environ. Sci. Eur. 31 , art. 10
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16992 Brack, W., Ait-Aissa, S., Burgess, R.M., Busch, W., Creusot, N., Di Paolo, C., Escher, B.I., Hewitt, L.M., Hilscherova, K., Hollender, J., Hollert, H., Jonker, W., Kool, J., Lamoree, M., Muschket, M., Neumann, S., Rostkowski, P., Ruttkies, C., Schollee, J., Schymanski, E.L., Schulze, T., Seiler, T.-B., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Krauss, M. (2016):
Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview
Sci. Total Environ. 544 , 1073 - 1118
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13987 Brack, W., Govender, S., Schulze, T., Krauss, M., Hu, M., Muz, M., Hollender, J., Schirmer, K., Schollee, J., Hidasi, A., Slobodnik, J., Rabova, Z., Ait-Aissa, S., Sonavane, M., Carere, M., Lamoree, M., Leonards, P., Tufi, S., Ouyang, X., Schriks, M., Thomas, K., de Almeida, A.C., Froment, J., Hammers-Wirtz, M., Ahel, M., Koprivica, S., Hollert, H., Seiler, T.-B., Di Paolo, C., Tindall, A., Spirhanzlova, P. (2013):
EDA-EMERGE: an FP7 initial training network to equip the next generation of young scientists with the skills to address the complexity of environmental contamination with emerging pollutants
Environ. Sci. Eur. 25 , art. 18
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18301 Deutschmann, B., Kolarevic, S., Brack, W., Kaisarevic, S., Kostic, J., Kracun-Kolarevic, M., Liska, I., Paunovic, M., Seiler, T.-B., Shao, Y., Sipos, S., Slobodnik, J., Teodorovic, I., Vukovic-Gacic, B., Hollert, H. (2016):
Longitudinal profile of the genotoxic potential of the River Danube on erythrocytes of wild common bleak (Alburnus alburnus) assessed using the comet and micronucleus assay
Sci. Total Environ. 573 , 1441 - 1449
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17926 Di Paolo, C., Kirchner, K., Balk, F.G.P., Muschket, M., Brack, W., Hollert, H., Seiler, T.-B. (2016):
Downscaling procedures reduce chemical use in androgen receptor reporter gene assay
Sci. Total Environ. 571 , 826 - 833
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17804 Di Paolo, C., Ottermanns, R., Keiter, S., Ait-Aissa, S., Bluhm, K., Brack, W., Breitholtz, M., Buchinger, S., Carere, M., Chalon, C., Cousin, X., Dulio, V., Escher, B.I., Hamers, T., Hilscherová, K., Jarque, S., Jonas, A., Maillot-Marechal, C., Marneffe, Y., Nguyen, M.T., Pandard, P., Schifferli, A., Schulze, T., Seidensticker, S., Seiler, T.-B., Tang, J., van der Oost, J., Vermeirssen, E., Zounková, R., Zwart, N., Hollert, H. (2016):
Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts – Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring
Water Res. 104 , 473 - 484
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15973 Di Paolo, C., Seiler, T.-B., Keiter, S., Hu, M., Muz, M., Brack, W., Hollert, H. (2015):
The value of zebrafish as an integrative model in effect-directed analysis - a review
Environ. Sci. Eur. 27 , art. 8
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14129 Grummt, T., Kuckelkorn, J., Bahlmann, A., Baumstark-Khan, C., Brack, W., Braunbeck, T., Feles, S., Gartiser, S., Glatt, H., Heinze, R., Hellweg, C.E., Hollert, H., Junek, R., Knauer, M., Kneib-Kissinger, B., Kramer, M., Krauss, M., Küster, E., Maletz, S., Meinl, W., Noman, A., Prantl, E.-M., Rabbow, E., Redelstein, R., Rettberg, P., Schadenboeck, W., Schmidt, C., Schulze, T., Seiler, T.-B., Spitta, L., Stengel, D., Waldmann, P., Eckhardt, A. (2013):
Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany. Tox-Box: die Tropfen des Lebens bewahren - gesundheitsbasierte Risikobewertung für Trinkwasser in Deutschland

Environ. Sci. Eur. 25 , art. 27
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12134 Higley, E., Grund, S., Jones, P.D., Schulze, T., Seiler, T.-B., Lübcke-von Varel, U., Brack, W., Wölz, J., Zielke, H., Giesy, J.P., Hollert, H., Hecker, M. (2012):
Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysis
Environ. Toxicol. Chem. 31 (5), 1053 - 1062
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19930 Hollert, H., Crawford, S.E., Brack, W., Brinkmann, M., Fischer, E., Hartmann, K., Keiter, S., Ottermanns, R., Ouellet, J.D., Rinke, K., Rösch, M., Roß-Nickoll, M., Schäffer, A., Schüth, C., Schulze, T., Schwarz, A., Seiler, T.-B., Wessels, M., Hinderer, M., Schwalb, A. (2018):
Looking back - Looking forward: A novel multi-time slice weight-of-evidence approach for defining reference conditions to assess the impact of human activities on lake systems
Sci. Total Environ. 626 , 1036 - 1046
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19745 Muschket, M., Di Paolo, C., Tindall, A.J., Touak, G., Phan, A., Krauss, M., Kirchner, K., Seiler, T.-B., Hollert, H., Brack, W. (2018):
Identification of unknown antiandrogenic compounds in surface waters by effect-directed analysis (EDA) using a parallel fractionation approach
Environ. Sci. Technol. 52 (1), 288 - 297
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16705 Neale, P.A., Ait-Aissa, S., Brack, W., Creusot, N., Denison, M.S., Deutschmann, B., Hilscherová, K., Hollert, H., Krauss, M., Novák, J., Schulze, T., Seiler, T.-B., Serra, H., Shao, Y., Escher, B.I. (2015):
Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling
Environ. Sci. Technol. 49 (24), 14614 - 14624
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19298 Neale, P.A., Altenburger, R., Aït-Aïssa, S., Brion, F., Busch, W., De Aragão Umbuzeiro, G., Denison, M.S., Du Pasquier, D., Hilscherová, K., Hollert, H., Morales, D.A., Novák, J., Schlichting, R., Seiler, T.-B., Serra, H., Shao, Y., Tindall, A.J., Tollefsen, K.E., Williams, T.D., Escher, B.I. (2017):
Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water
Water Res. 123 , 734 - 750
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18079 Neale, P.A., Munz, N.A., Aїt-Aїssa, S., Altenburger, R., Brion, F., Busch, W., Escher, B.I., Hilscherová, K., Kienle, C., Novák, J., Seiler, T.-B., Shao, Y., Stamm, C., Hollender, J. (2017):
Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams
Sci. Total Environ. 576 , 785 - 795
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25091 Schmitz, M., Deutschmann, B., Markert, N., Backhaus, T., Brack, W., Brauns, M., Brinkmann, M., Seiler, T.-B., Fink, P., Tang, S., Beitel, S., Doering, J.A., Hecker, M., Shao, Y., Schulze, T., Weitere, M., Wild, R., Velki, M., Hollert, H. (2022):
Demonstration of an aggregated biomarker response approach to assess the impact of point and diffuse contaminant sources in feral fish in a small river case study
Sci. Total Environ. 804 , art. 150020
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18284 Schulze, T., Ahel, M., Ahlheim, J., Aït-Aïssa, S., Brion, F., Di Paolo, C., Froment, J., Hidasi, A.O., Hollender, J., Hollert, H., Hu, M., Kloß, A., Koprivica, S., Krauss, M., Muz, M., Oswald, P., Petre, M., Schollée, J.E., Seiler, T.-B., Shao, Y., Slobodnik, J., Sonavane, M., Suter, M.J.-F., Tollefsen, K.E., Tousova, Z., Walz, K.-H., Brack, W. (2017):
Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis
Sci. Total Environ. 581–582 , 350 - 358
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16310 Schulze, T., Krauss, M., Novak, J., Hilscherova, K., Ait-Aissa, S., Creusot, N., Macova, M., Neale, P., Escher, B.I., Gomes, T., Tollefsen, K.E., Tarcai, Z., Shao, Y., Deutschmann, B., Seiler, T.-B., Hollert, H., Tarabek, P., Tousova, Z., Slobodnik, J., Walz, K.-H., Brack, W. (2015):
Large volume sampling and effect-based screening
In: Liška, I., Wagner, F., Sengl, M., Deutsch, K., Slobodník, J. (eds.)
Joint Danube Survey 3 : a comprehensive analysis of Danube water quality
International Commission for the Protection of the Danube River (ICPDR), Vienna, p. 284 - 295
12707 Schulze, T., Seiler, T.-B., Streck, G., Braunbeck, T., Hollert, H. (2012):
Comparison of different exhaustive and biomimetic extraction techniques for chemical and biological analysis of polycyclic aromatic compounds in river sediments
J. Soils Sediments 12 (9), 1419 - 1434
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1447 Seiler, T.-B., Schulze, T., Hollert, H. (2008):
The risk of altering soil and sediment samples upon extract preparation for analytical and bio-analytical investigations - a review
Anal. Bioanal. Chem. 390 (8), 1975 - 1985
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21582 Shao, Y., Chen, Z., Hollert, H., Zhou, S., Deutschmann, B., Seiler, T.-B. (2019):
Toxicity of 10 organic micropollutants and their mixture: Implications for aquatic risk assessment
Sci. Total Environ. 666 , 1273 - 1282
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21028 Shao, Y., Hollert, H., Tarcai, Z., Deutschmann, B., Seiler, T.-B. (2019):
Integrating bioassays, chemical analysis and in silico techniques to identify genotoxicants in surface water
Sci. Total Environ. 650 (Part 2), 3084 - 3092
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20659 Tousova, Z., Oswald, P., Slobodnik, J., Blaha, L., Muz, M., Hu, M., Brack, W., Krauss, M., Di Paolo, C., Tarcai, Z., Seiler, T.-B., Hollert, H., Koprivica, S., Ahel, M., Schollée, J.E., Hollender, J., Suter, M.J.-F., Hidasi, A.O., Schirmer, K., Sonavane, M., Ait-Aissa, S., Creusot, N., Brion, F., Froment, J., Almeida, A.C., Thomas, K., Tollefsen, K.E., Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Kolkman, A., Schriks, M., Spirhanzlova, P., Tindall, A., Schulze, T. (2018):
Corrigendum to “European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters” [Sci. Total Environ. 601–602 (2017) 1849–1868]
Sci. Total Environ. 635 , 1620 - 1621
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18907 Tousova, Z., Oswald, P., Slobodnik, J., Blaha, L., Muz, M., Hu, M., Brack, W., Krauss, M., Di Paolo, C., Tarcai, Z., Seiler, T.-B., Hollert, H., Koprivica, S., Ahel, M., Schollée, J.E., Hollender, J., Suter, M.J.-F., Hidasi, A.O., Schirmer, K., Sonavane, M., Ait-Aissa, S., Creusot, N., Brion, F., Froment, J., Almeida, A.C., Thomas, K., Tollefsen, K.E., Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Kolkman, A., Schriks, M., Spirhanzlova, P., Tindall, A., Schulze, T. (2017):
European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters
Sci. Total Environ. 601-602 , 1849 - 1868
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23800 Zhou, S., Peng, S., Brack, W., Doering, J.A., Seiler, T.-B., Hollert, H. (2021):
Bioanalytical equivalents and relative potencies for predicting the biological effects of mixtures
Sci. Total Environ. 763 , art. 143030
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10886 Zielke, H., Seiler, T.-B., Niebergall, S., Leist, E., Brinkmann, M., Spira, D., Streck, G., Brack, W., Feiler, U., Braunbeck, T., Hollert, H. (2011):
The impact of extraction methodologies on the toxicity of sediments in the zebrafish (Danio rerio) embryo test
J. Soils Sediments 11 (2), 352 - 363
full text (doi)
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