Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1007/BF02986390 |
| Volltext | Shareable Link |
| Titel (primär) | Antiestrogenic activity of anthropogenic and natural chemicals |
| Autor | Navas, J.M.; Segner, H. |
| Quelle | Environmental Science and Pollution Research |
| Erscheinungsjahr | 1998 |
| Department | OEC; COE |
| Band/Volume | 5 |
| Heft | 2 |
| Seite von | 75 |
| Seite bis | 82 |
| Sprache | englisch |
| Abstract | A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes. |
| Navas, J.M., Segner, H. (1998): Antiestrogenic activity of anthropogenic and natural chemicals Environ. Sci. Pollut. Res. 5 (2), 75 - 82 10.1007/BF02986390 |
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