Details zur Publikation |
Kategorie | Textpublikation |
Referenztyp | Zeitschriften |
DOI | 10.1007/BF02986390 |
Volltext | Shareable Link |
Titel (primär) | Antiestrogenic activity of anthropogenic and natural chemicals |
Autor | Navas, J.M.; Segner, H. |
Quelle | Environmental Science and Pollution Research |
Erscheinungsjahr | 1998 |
Department | OEC; COE |
Band/Volume | 5 |
Heft | 2 |
Seite von | 75 |
Seite bis | 82 |
Sprache | englisch |
Abstract | A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes. |
dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=8878 |
Navas, J.M., Segner, H. (1998): Antiestrogenic activity of anthropogenic and natural chemicals Environ. Sci. Pollut. Res. 5 (2), 75 - 82 10.1007/BF02986390 |