Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1177/1420326X03035167 |
| Titel (primär) | Indoor mould exposure reduces Th1 reactivity in early childhood |
| Autor | Lehmann, I.; Müller, A.; Diez, U.; Richter, M.; Wallach, S.; Sierig, G.; Seiffart, A.; Wetzig, H.; Borte, M.; Herbarth, O. |
| Journal / Serie | Indoor and Built Environment |
| Erscheinungsjahr | 2003 |
| Department | IMMU; EXPOEPID |
| Band/Volume | 12 |
| Heft | 4 |
| Seite von | 231 |
| Seite bis | 233 |
| Sprache | englisch |
| Keywords | Indoor mould; Allergy; Children; T cells; IFN-g; IL-4; Th1 cells; Th2 cells |
| Abstract | A birth cohort study (LARS - Leipzig Allergy Risk Children Study) was used to investigate the influence of indoor mould exposure on T cell function in early childhood. T cell cytokines (IFN-g, IL-4) were analysed in a sub-group of the LARS cohort (birth: n = 39, 6 months: n = 11, 12 months: n = 50, 36 months: n = 33). Mould burden was assessed by analysis of questionnaires completed at the birth of the child and measurement of indoor mould spores was carried out when the children were 3 years old. Children whose parents reported mould burden or dampness in their dwellings at the time of birth showed lower amounts of IFN-g producing Th1 cells during the first year of life (significant at 12 months) in comparison to unexposed children. The capacity to produce IL-4 was not altered, however. When the children were 3 years old, an association between measured indoor mould and suppressed Th1 reactivity was observed. The data suggest that indoor mould exposure is associated with reduced Th1 reactivity in early childhood. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=5034 |
| Lehmann, I., Müller, A., Diez, U., Richter, M., Wallach, S., Sierig, G., Seiffart, A., Wetzig, H., Borte, M., Herbarth, O. (2003): Indoor mould exposure reduces Th1 reactivity in early childhood Indoor Built Environ. 12 (4), 231 - 233 |
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