Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1897/02-450
Volltext Shareable Link
Titel (primär) Identification of toxic products of anthracene photomodification in simulated sunlight
Autor Brack, W.; Altenburger, R.; Küster, E. ORCID logo ; Meissner, B.; Wenzel, K.-D.; Schüürmann, G.
Quelle Environmental Toxicology and Chemistry
Erscheinungsjahr 2003
Band/Volume 22
Heft 10
Seite von 2228
Seite bis 2237
Sprache englisch
Keywords Effect-directed analysis; Photomodification; Anthracene; Anthracene-1,4-dione
Abstract Currently, the evidence of a rapid photomodification of anthracene under sunlight resulting in enhanced toxicity exists; however, the chemical causes of toxicity are still unknown. The present study aimed at filling this gap by irradiation of an anthracene suspension with simulated sunlight and subsequent effect-directed fractionation and analysis of toxic products with respect to the inhibition of bacterial energy metabolism of Vibrio fischeri, reproduction of the green algae Scenedesmus vacuolatus, and genotoxicity in the umuC test. Algal toxicity of anthracene was hardly modified by irradiation prior to testing and distributed over all fractions with emphasis on the fractions containing anthracene-9,10-dione and a photometabolite suggested to be 10-hydroxyanthrone. Bacterial toxicity and genotoxicity in contrast emerged only when anthracene was irradiated. Anthracene-1,4-dione, a sofar-unknown trace photometabolite, was identified as a very potent toxicant dominating the toxicity of photomodified anthracene to V. fischeri. In genotoxic fractions, 1-hydroxyanthracene-9,10-dione and 1,4-dihydroxyanthracene-9,10-dione were identified and confirmed as genotoxicants. The results stress the potential of effect-directed analysis approaches in contrast to mere chemical analysis in studies aiming at toxicologically relevant photomodified substances.
dauerhafte UFZ-Verlinkung
Brack, W., Altenburger, R., Küster, E., Meissner, B., Wenzel, K.-D., Schüürmann, G. (2003):
Identification of toxic products of anthracene photomodification in simulated sunlight
Environ. Toxicol. Chem. 22 (10), 2228 - 2237 10.1897/02-450