Details zur Publikation
|Titel (primär)||Reaction kinetic monitoring by high performance liquid chromatography coupled to mass spectrometry: oxidation processes of selected isothiazoles|
|Autor||Baumann, S.; Möder, M.; Herzschuh, R.; Schulze, B.|
|Journal / Serie||Chromatographia|
A HPLC-MS(MS) method is presented here for reaction monitoring of the oxidation of isothiazolium salts with H2O2/acetic acid. The comprehension of this mechanism was the aim of this work using several N-functionalized substances for the investigation. The strong acidic reaction mixture was separated on a RP-18 reversed-phased column without any sample pretreatment and occurring intermediates were identified by API-MS(MS) techniques. Thus, it was possible to gain detailed information about the course of oxidation and to develop an oxidation scheme of existing reaction pathways.
|Baumann, S., Möder, M., Herzschuh, R., Schulze, B. (2003):
Reaction kinetic monitoring by high performance liquid chromatography coupled to mass spectrometry: oxidation processes of selected isothiazoles
Chromatographia 57 (1 Suppl.), 147 - 152