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Referenztyp Zeitschriften
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Titel (primär) Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Autor Seshadri, R.; Adrian, L.; Fouts, D.E.; Eisen, J.A.; Phillippy, A.M.; Methe, B.A.; Ward, N.L.; Nelson, W.C.; Deboy, R.T.; Khouri, H.M.; Kolonay, J.F.; Dodson, R.J.; Daugherty, S.C.; Brinkac, L.M.; Sullivan, S.A.; Madupu, R.; Nelson, K.T.; Kang, K.H.; Impraim, M.; Tran, K.; Robinson, J.M.; Forberger, H.A.; Fraser, C.M.; Zinder, S.H.; Heidelberg, J.F.;
Journal / Serie Science
Erscheinungsjahr 2005
Department ISOBIO;
Band/Volume 307
Heft 5706
Sprache englisch;
Abstract Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720-base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H-2. Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph
ID 3802
dauerhafte UFZ-Verlinkung
Seshadri, R., Adrian, L., Fouts, D.E., Eisen, J.A., Phillippy, A.M., Methe, B.A., Ward, N.L., Nelson, W.C., Deboy, R.T., Khouri, H.M., Kolonay, J.F., Dodson, R.J., Daugherty, S.C., Brinkac, L.M., Sullivan, S.A., Madupu, R., Nelson, K.T., Kang, K.H., Impraim, M., Tran, K., Robinson, J.M., Forberger, H.A., Fraser, C.M., Zinder, S.H., Heidelberg, J.F. (2005):
Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Science 307 (5706), 105 - 108