Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1126/science.1102226
Titel (primär) Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Autor Seshadri, R.; Adrian, L.; Fouts, D.E.; Eisen, J.A.; Phillippy, A.M.; Methe, B.A.; Ward, N.L.; Nelson, W.C.; Deboy, R.T.; Khouri, H.M.; Kolonay, J.F.; Dodson, R.J.; Daugherty, S.C.; Brinkac, L.M.; Sullivan, S.A.; Madupu, R.; Nelson, K.T.; Kang, K.H.; Impraim, M.; Tran, K.; Robinson, J.M.; Forberger, H.A.; Fraser, C.M.; Zinder, S.H.; Heidelberg, J.F.
Journal / Serie Science
Erscheinungsjahr 2005
Department ISOBIO
Band/Volume 307
Heft 5706
Seite von 105
Seite bis 108
Sprache englisch
Abstract Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720-base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H-2. Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph
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Seshadri, R., Adrian, L., Fouts, D.E., Eisen, J.A., Phillippy, A.M., Methe, B.A., Ward, N.L., Nelson, W.C., Deboy, R.T., Khouri, H.M., Kolonay, J.F., Dodson, R.J., Daugherty, S.C., Brinkac, L.M., Sullivan, S.A., Madupu, R., Nelson, K.T., Kang, K.H., Impraim, M., Tran, K., Robinson, J.M., Forberger, H.A., Fraser, C.M., Zinder, S.H., Heidelberg, J.F. (2005):
Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Science 307 (5706), 105 - 108