Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1007/s00706-005-0320-0 |
| Volltext | Shareable Link |
| Titel (primär) | Current methods for determination of L-carnitine and acylcarnitines |
| Autor | Möder, M.; Kießling, A.; Löster, H. |
| Quelle | Monatshefte für Chemie |
| Erscheinungsjahr | 2005 |
| Department | ANA |
| Band/Volume | 136 |
| Heft | 8 |
| Seite von | 1279 |
| Seite bis | 1291 |
| Sprache | englisch |
| Abstract | L-Carnitine as endogenous compound plays an important role within several metabolic pathways and a deficiency of L-carnitine can cause adverse effects in physiological and/or mental state of health and disease. The prevention of diseases related to carnitine deficiency requires, first of all, the exact determination of L-carnitine and its esters in biological material at pmol/cm3 level. A series of analytical procedures based on biochemical assays as well as on physical methods are available today. Determination of free and total carnitine is sometimes sufficient for a clinical diagnosis, but in most cases, such as in newborn screening for genetic disorders, detailed qualitative and quantitative L-carnitine/acylcarnitine profiling is needed. Technological progress has also revolutionized the determination of carnitines. Today, comprehensive and diagnostically relevant information can be obtained by mass spectrometry. An overview is given of the technical and methodological developments in carnitine analysis and some applications, such as in neonatal screening, diabetes mellitus, and cardiomyopathy. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=3629 |
| Möder, M., Kießling, A., Löster, H. (2005): Current methods for determination of L-carnitine and acylcarnitines Mon. Chem. 136 (8), 1279 - 1291 10.1007/s00706-005-0320-0 |
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