Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Genome sequence of the chlorinated compound respiring bacterium Dehalococcoides species strain CBDB1
Autor Kube, M.; Beck, A.; Zinder, S.H.; Kuhl, H.; Reinhardt, R.; Adrian, L.;
Journal / Serie Nature Biotechnology
Erscheinungsjahr 2005
Department ISOBIO;
Band/Volume 23
Heft 10
Sprache englisch;
Abstract Dehalococcoides species are strictly anaerobic bacteria, which catabolize many of the most toxic and persistent chlorinated aromatics and aliphatics by reductive dechlorination and are used for in situ bioremediation of contaminated sites. Our sequencing of the complete 1,395,502 base pair genome of Dehalococcoides strain CBDB1 has revealed the presence of 32 reductive-dehalogenase-homologous (rdh) genes, possibly conferring on the bacteria an immense dehalogenating potential. Most rdh genes were associated with genes encoding transcription regulators such as two-component regulatory systems or transcription regulators of the MarR-type. Four new paralog groups of rdh-associated genes without known function were detected. Comparison with the recently sequenced genome of Dehalococcoides ethenogenes strain 195 reveals a high degree of gene context conservation (synteny) but exceptionally high plasticity in all regions containing rdh genes, suggesting that these regions are under intense evolutionary pressure.
ID 3544
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=3544
Kube, M., Beck, A., Zinder, S.H., Kuhl, H., Reinhardt, R., Adrian, L. (2005):
Genome sequence of the chlorinated compound respiring bacterium Dehalococcoides species strain CBDB1
Nat. Biotechnol. 23 (10), 1269 - 1273