Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s41467-026-76948-9 |
Lizenz  |
|
| Titel (primär) | CD97/ADGRE5 attenuates the induction of adaptive type 2 immune responses in allergic asthma |
| Autor | Aust, G.; Hoh, A.-L.; Alladina, J.; Smith, N.P.; Höhna, F.; Wang, B.; Kerner, C.; Wagner, M.; Krohn, K.; Pierzchalski, A.; Häussler, N.; Villani, A.C.; Cho, J.L.; Medoff, B.D.; Zenclussen, A.C.; Steinert, M.; Hamann, J.; Quaas, M.; Polte, T. |
| Quelle | Nature Communications |
| Erscheinungsjahr | 2026 |
| Department | IMMU |
| Band/Volume | 17 |
| Seite von | art. 9226 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | Supplement 1 Supplement 2 Supplement 3 |
| Abstract | Allergic asthma results from an uncontrolled type 2 immune response to inhaled allergens. Here, we investigate the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in this disease. Female Cd97−/− mice exhibit an exacerbated asthmatic phenotype across multiple models, primarily due to CD97 loss on immune cells. A single CD97 antibody treatment before allergen sensitization worsens allergic responses, highlighting a role for CD97 in early immune regulation. Post-sensitization, Cd97−/− mice display higher frequencies of lung conventional type 2 and monocyte-derived dendritic cells (DCs). Allergen-pulsed Cd97−/− bone marrow-derived DCs are more activated, promote enhanced proliferation and type 2 cytokine secretion by CD4⁺ OT-II cells, and induce stronger airway inflammation. Consistently, ADGRE5 expression is reduced in airway mucosa-derived mononuclear phagocyte subsets in human asthmatics after allergen-induced exacerbation. These results identify CD97 as an important regulator of DC-driven type 2 allergic responses and a potential target in asthma. |
| Aust, G., Hoh, A.-L., Alladina, J., Smith, N.P., Höhna, F., Wang, B., Kerner, C., Wagner, M., Krohn, K., Pierzchalski, A., Häussler, N., Villani, A.C., Cho, J.L., Medoff, B.D., Zenclussen, A.C., Steinert, M., Hamann, J., Quaas, M., Polte, T. (2026): CD97/ADGRE5 attenuates the induction of adaptive type 2 immune responses in allergic asthma Nat. Commun. 17 , art. 9226 10.1038/s41467-026-76948-9 |
|