Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s41467-026-74942-9 |
Lizenz  |
|
| Titel (primär) | Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression |
| Autor | Diab, N.; Yong, C.H.; Stange, E.-L.; Birk, M.S.; Schmitz, M.A.; Düsterhöft, S.; Pes, J.; Ferle, K.M.; Karkossa, I.; Schubert, K.; Deiwick, J.; Vucur, M.; Luedde, T.; Torow, N.; Ludwig, A.; Dupont, A.; Selkrig, J.; von Bergen, M.; Hensel, M.; Zhang, K.; Hornef, M.W. |
| Quelle | Nature Communications |
| Erscheinungsjahr | 2026 |
| Department | iDiv; MOLTOX |
| Band/Volume | 17 |
| Seite von | art. 5884 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | Supplement 1 Supplement 2 |
| Abstract | Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) manipulates cellular processes through the translocation of effector molecules into the host cell cytosol. Using a recently established neonatal S. Typhimurium infection model, we provide functional insights into how Salmonella outer protein B (SopB) suppresses early mucosal tissue inflammation and prolongs host survival. Mechanistically, SopB prevents a disintegrin and metalloprotease 17 (ADAM17) activation, plasma membrane translocation and the release of membrane-bound TNFα from enterocytes and reduces epithelial secretion of IL-18 via mTOR-controlled secretory autophagy. This abolishes the early epithelial transcriptional response and reduces immune cell recruitment and programmed cell death-mediated mucosal barrier disruption delaying disease progression. The immunosuppressive effect of SopB is independent of the C-terminally encoded phosphatidylinositol phosphatase and phosphotransferase activity but requires an intact N-terminal domain. Also, it is restricted to the neonatal mouse model characterised by Salmonella pathogenicity island (SPI)1 type 3 secretion system (T3SS)-dependent enterocyte invasion-driven mucosal translocation. Thus, here we demonstrate that SopB suppresses the early, post-transcriptional regulation of epithelial cytokine release in an inositol phosphatase-independent manner likely promoting pathogen transmission. |
| Diab, N., Yong, C.H., Stange, E.-L., Birk, M.S., Schmitz, M.A., Düsterhöft, S., Pes, J., Ferle, K.M., Karkossa, I., Schubert, K., Deiwick, J., Vucur, M., Luedde, T., Torow, N., Ludwig, A., Dupont, A., Selkrig, J., von Bergen, M., Hensel, M., Zhang, K., Hornef, M.W. (2026): Salmonella SopB suppresses post-transcriptionally regulated cytokine release to reduce early tissue inflammation and delay disease progression Nat. Commun. 17 , art. 5884 10.1038/s41467-026-74942-9 |
|