This data descriptor paper presents version 2.0 of the Database of Flood Fatalities in the Euro-Mediterranean Region (FFEM-DB 2.0), a multinational dataset documenting 3,737 flood fatalities that occurred from 1980 to 2024 across 16 territories (12 of which correspond to entire countries). FFEM-DB 2.0 substantially expands the spatial and temporal coverage of the previous release (FFEM-DB) by updating records through December 31, 2024, incorporating four additional study areas, and introducing a new event identifier that allows event-based analyses and comparison with international disaster databases. The database provides anonymized information on victims’ profiles, accident locations, and fatality circumstances, enabling systematic investigation of demographic, behavioral, situational, and environmental factors associated with flood mortality at the scale of LAU (Local Administrative Units). Standardized data collection criteria and a harmonized classification methodology ensure consistency and comparability across regions beyond administrative boundaries, while also highlighting variations in data completeness across the study areas. Due to its open and scalable structure, FFEM-DB 2.0 enables continuous spatial expansion and temporal updates, providing a basis for monitoring and interpreting current trends in flood-related mortality across Europe and the Euro-Mediterranean region.