Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.envres.2026.124218 |
Lizenz  |
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| Titel (primär) | Effect-based methods and effect-based trigger values for estrogenicity monitoring in surface water: an interlaboratory study |
| Autor | Gómez, L.; Marinov, D.; Porcel-Rodríguez, E.; Scaccabarozzi, D.; Sanseverino, I.; Sciuto, P.; Narendja, F.; Hornek-Gausterer, R.; Lenz, K.; Chalon, C.; Marneffe, Y.; Soldán, P.; Hora, M.; Leppänen, M.T.; Järvistö, J.; Viidanoja, J.; Ait-Aissa, S.; Maillot-Marechal, E.; El Mais, A.E.R.; Escher, B.I.
; König, M.; Hollert, H.; Wollenweber, S.; Buchinger, S.; Ohlig, M.; Pedrazzani, R.; Lundqvist, J.; Oskarsson, A.; Vermeirssen, E.; Maletz, S.; Olbrich, D.; Mehinto, A.C.; Wong, K.; Denslow, N.; Amendola, L.; Gil-Solsona, R.; Gago-Ferrero, P.; Potalivo, M.; Carere, M.; Lettieri, T. |
| Quelle | Environmental Research |
| Erscheinungsjahr | 2026 |
| Department | ZELLTOX |
| Band/Volume | 298 |
| Seite von | art. 124218 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | Supplement 1 Supplement 2 |
| Keywords | Bioassays; Safety thresholds; Water quality monitoring; Chemical mixtures; Hormones; Endocrine-disrupting chemicals |
| Abstract | Effect-based
methods (EBMs) may be included in the European Water Framework
Directive (WFD) to evaluate estrogenic substances. The European
Commission's Joint Research Centre conducted an interlaboratory study to
assess estrogenic EBMs and effect-based trigger (EBTs) values derived
using three options: (1) linking the EBT value to environmental quality
standards (EQS), (2) correlating in vitro and in vivo
data, and (3) averaging bioassay-specific EBT values. Surface water
samples from eight Northern-Italian sites containing estrogenic hormones
and endocrine-disrupting chemicals (EDCs) were analysed by fourteen
laboratories employing EBMs, while four laboratories performed chemical
analysis. Chemical data indicated cumulative risk in several samples,
with estrone and bisphenol A identified as main drivers. All EBMs
detected estrogenic activity, but specificity differed: some bioassays
responded mainly to hormones, whereas others also responded to
non-hormonal EDCs. EBMs flagged estrogenic risk in a sample that showed
no individual exceedances of EQS. Applying EBT option 1 yielded the
highest concordance with chemical results, achieving full compliance in
eight bioassays and proven to be the most protective. Indeed, option 2
reduced the risk quotient (RQ) by > 30%, leading to two bioassays in
full compliance, while Option 3 resulted in RQ changes (<20%) for
most EBMs, with seven bioassays in full compliance with chemical
analysis. The study underscores the need to harmonise EBMs – including data evaluation – to address chemical mixtures and provides recommendations for Member States on their application in the WFD. Integrating EBMs with conventional monitoring enhances protection against cumulative estrogenic risks from both hormones and EDCs. |
| Gómez, L., Marinov, D., Porcel-Rodríguez, E., Scaccabarozzi, D., Sanseverino, I., Sciuto, P., Narendja, F., Hornek-Gausterer, R., Lenz, K., Chalon, C., Marneffe, Y., Soldán, P., Hora, M., Leppänen, M.T., Järvistö, J., Viidanoja, J., Ait-Aissa, S., Maillot-Marechal, E., El Mais, A.E.R., Escher, B.I., König, M., Hollert, H., Wollenweber, S., Buchinger, S., Ohlig, M., Pedrazzani, R., Lundqvist, J., Oskarsson, A., Vermeirssen, E., Maletz, S., Olbrich, D., Mehinto, A.C., Wong, K., Denslow, N., Amendola, L., Gil-Solsona, R., Gago-Ferrero, P., Potalivo, M., Carere, M., Lettieri, T. (2026): Effect-based methods and effect-based trigger values for estrogenicity monitoring in surface water: an interlaboratory study Environ. Res. 298 , art. 124218 10.1016/j.envres.2026.124218 |
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