The QUADICA version 2 dataset significantly expands upon the first version of QUADICA (water QUAlity, DIscharge and Catchment Attributes for large-sample studies in Germany), by incorporating more recent data, additional water quality and driver variables, and more stations with concurrent water quantity data. Specifically, QUADICA v2 extends the water quality time series of the first version up to 2020 and introduces new variables, including water temperature, oxygen, and chlorophyll a concentrations, as well as concentrations of ammonium, sulfate, and geogenic solutes like calcium. These additions enable a more comprehensive understanding of ecological impacts, including eutrophication effects, and water quality dynamics across catchments. Furthermore, the number of stations with both water quality and quantity data has effectively doubled – now covering 637 out of the total 1386 stations – by integrating QUADICA with the CAMELS-DE and Caravan-DE datasets. The inclusion of time series on point and diffuse sources of both nitrogen and phosphorus allows for more thorough investigations of driver-response relationships and nutrient export from catchments. To facilitate visualization and exploration of QUADICA, we provide a user-friendly, interactive R application alongside the online data repository, as well as a browser-based web app for inspecting the dataset. This makes QUADICA v2 a comprehensive dataset that spans from driver to impact variables, offering a valuable resource for researchers and practitioners. QUADICA v2 is available at https://doi.org/10.4211/hs.c2866cd416b94ca386deb5758834311f (Ebeling et al., 2025).