Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1007/s10334-025-01235-5 |
Lizenz  |
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| Titel (primär) | Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data |
| Autor | Dega, S.; Ferreira, M.; Veldmann, M.; Stirnberg, R.; Paasche, H.; Stöcker, T. |
| Quelle | Magnetic Resonance Materials in Physics Biology and Medicine |
| Erscheinungsjahr | 2025 |
| Department | MET |
| Band/Volume | 38 |
| Heft | 2 |
| Seite von | 317 |
| Seite bis | 332 |
| Sprache | englisch |
| Topic | T5 Future Landscapes |
| Supplements | https://static-content.springer.com/esm/art%3A10.1007%2Fs10334-025-01235-5/MediaObjects/10334_2025_1235_MOESM1_ESM.docx |
| Keywords | Myelin water imaging; Myelin water fraction; T2 and T*2 relaxation spectra; Joint inversion |
| Abstract | Objective Accurate estimation of brain myelin-water content from multi-echo data is challenging due to the inherent ill-posedness of the inversion problem. In this study, we propose a novel method for myelin-water imaging that jointly utilizes gradient-echo and spin-echo imaging data to enhance the accuracy of myelin-water estimation. Material and methods Multi-echo gradient-echo and spin-echo data were simulated and acquired in vivo. The simulations are based on a parameterized myelin and free water signal model, which is also used for the inversion by means of nonlinear local-search optimization. Single inversions of the individual datasets as well as joint inversion of the combined datasets were performed on simulated and real data. While single inversions estimate either the T2 or T2* relaxation spectrum, the joint inversion estimates both spectra simultaneously. Results Simulation results show that the accuracy of myelin-water imaging improves when jointly inverting gradient-echo and spin-echo synthetic data. In vivo experiments show that the joint inversion of both datasets leads to sharper and more distinct myelin-water images as compared to the individual inversions. Discussion Our method addresses the ill-posed nature of the myelin-water inversion problem by leveraging complementary information from multi-echo gradient-echo and multi-echo spin-echo imaging sequences, thus improving the reliability of myelin-water quantification. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=30596 |
| Dega, S., Ferreira, M., Veldmann, M., Stirnberg, R., Paasche, H., Stöcker, T. (2025): Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data Magn. Reson. Mat. Phys. Biol. Med. 38 (2), 317 - 332 10.1007/s10334-025-01235-5 |
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