Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1186/s12302-024-01025-1 |
Lizenz  |
|
| Titel (primär) | Non-extractable residues (NER) in persistence assessment: effect on the degradation half-life of chemicals |
| Autor | Jespersen, C.; Trapp, S.; Kästner, M. |
| Quelle | Environmental Sciences Europe |
| Erscheinungsjahr | 2024 |
| Department | MEB |
| Band/Volume | 36 |
| Seite von | art. 206 |
| Sprache | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://static-content.springer.com/esm/art%3A10.1186%2Fs12302-024-01025-1/MediaObjects/12302_2024_1025_MOESM1_ESM.docx |
| Keywords | Bound residues; DT50; DegT50; Microbial turnover to biomass; Pesticides; bioNER; XenoNER; PBT; Risk assessment; REACH |
| Abstract | The
ECHA guidance on persistence (P) assessment has been updated with
respect to non-extractable residues (NER). Unless further characterized,
total NER shall be considered as non-degraded parent compound. We
investigated how different NER fractions affect degradation half-lives
(DegT50) of chemicals and the P assessment. Total NER consists of the
fractions sorbed/sequestered (NER I), covalently bound (NER II), and
bioNER (incorporated into the biomass, NER III). NER I pose a risk due
to potential release, NER II have much lower release potential, and
bioNER do not have any. Data from 46 degradation tests with 24 substances were analyzed to find DegT50 for four scenarios: i) extractable parent compound, ii) parent plus total NER, iii) parent plus xenoNER, and iv) parent plus NER I. The Microbial Turnover to Biomass (MTB) model was applied to calculate bioNER, and then xenoNER were calculated as total NER minus bioNER. The half-lives were determined by the fit program CAKE, using single first-order kinetics (SFO) for all fits. We found increasing degradation half-lives for the scenarios: parent only < parent + NER I < parent + xenoNER < parent + total NER. A third of all chemicals show half-lives above the persistence criterion (120 days in OECD 307) for scenario i, and two thirds with scenario ii and, therefore, would be classified as 'persistent´. For two compounds, the subtraction of bioNER led to a change to 'not persistent´. The inclusion of NER will thus have significant effects on the DegT50 of compounds and the persistence assessment. Experimental quantification of NER I (scenario iv) significantly reduces half-lives, in comparison to total NER (scenario ii). The results are closer to half-lives for parent only (scenario i) and give the lowest acceptable DegT50 below the vP criteria under the latest guidance. In addition, refining the DegT50 based on modelled bioNER can provide a relevant option for persistence assessment, without laborious and costly analyses for NER I determination, when considered in the regulatory assessment of persistence. Moreover, bioNER can also be calculated for existing test data. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29959 |
| Jespersen, C., Trapp, S., Kästner, M. (2024): Non-extractable residues (NER) in persistence assessment: effect on the degradation half-life of chemicals Environ. Sci. Eur. 36 , art. 206 10.1186/s12302-024-01025-1 |
|