Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1093/cid/ciab588 |
Lizenz  |
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| Titel (primär) | Characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting |
| Autor | Walker, A.; Houwaart, T.; Finzer, P.; Ehlkes, L.; Tyshaieva, A.; Damagnez, M.; Strelow, D.; Nunes da Rocha, U.; Rosenstiel, P., et al. |
| Quelle | Clinical Infectious Diseases |
| Erscheinungsjahr | 2022 |
| Department | UMB |
| Band/Volume | 74 |
| Heft | 6 |
| Seite von | 1039 |
| Seite bis | 1046 |
| Sprache | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://academic.oup.com/cid/article/74/6/1039/6310838?login=true#supplementary-data |
| Keywords | genomic epidemiology, infection chain; community transmission; rapid sequencing; Nanopore sequencing |
| Abstract | Background Tracing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission chains is still a major challenge for public health authorities, when incidental contacts are not recalled or are not perceived as potential risk contacts. Viral sequencing can address key questions about SARS-CoV-2 evolution and may support reconstruction of viral transmission networks by integration of molecular epidemiology into classical contact tracing. Methods In collaboration with local public health authorities, we set up an integrated system of genomic surveillance in an urban setting, combining a) viral surveillance sequencing, b) genetically based identification of infection clusters in the population, c) integration of public health authority contact tracing data, and d) a user-friendly dashboard application as a central data analysis platform. Results Application of the integrated system from August to December 2020 enabled a characterization of viral population structure, analysis of 4 outbreaks at a maximum care hospital, and genetically based identification of 5 putative population infection clusters, all of which were confirmed by contact tracing. The system contributed to the development of improved hospital infection control and prevention measures and enabled the identification of previously unrecognized transmission chains, involving a martial arts gym and establishing a link between the hospital to the local population. Conclusions Integrated systems of genomic surveillance could contribute to the monitoring and, potentially, improved management of SARS-CoV-2 transmission in the population. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29557 |
| Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Nunes da Rocha, U., Rosenstiel, P., et al. (2022): Characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting Clin. Infect. Dis. 74 (6), 1039 - 1046 10.1093/cid/ciab588 |
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