Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1021/acs.analchem.4c01958 |
Lizenz  |
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| Titel (primär) | Modular chip-based nanoSFC–MS for ultrafast separations |
| Autor | Weise, C.; Schirmer, M.; Polack, M.; Korell, A.; Westphal, H.; Schwieger, J.; Warias, R.; Zimmermann, S.; Belder, D. |
| Quelle | Analytical Chemistry |
| Erscheinungsjahr | 2024 |
| Department | SOMA |
| Band/Volume | 96 |
| Heft | 34 |
| Seite von | 13888 |
| Seite bis | 13896 |
| Sprache | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://pubs.acs.org/doi/suppl/10.1021/acs.analchem.4c01958/suppl_file/ac4c01958_si_001.pdf |
| Abstract | This study presents the development of a miniaturized device for supercritical fluid chromatography coupled with mass spectrometry. The chip-based, modular nanoSFC approach utilizes a particle-packed nanobore column embedded between two monolithically structured glass chips. A microtee in the pre-column section ensures picoliter sample loads onto the column, while a microcross chip structure fluidically controls the column backpressure. The restrictive emitter and the minimal post-column volume of 16 nL prevent mobile phase decompression and analyte dilution, maintaining chromatographic integrity during transfer to the atmospheric pressure MS interface. This facilitates high-speed chiral separations in less than 80 s with high reproducibility. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29537 |
| Weise, C., Schirmer, M., Polack, M., Korell, A., Westphal, H., Schwieger, J., Warias, R., Zimmermann, S., Belder, D. (2024): Modular chip-based nanoSFC–MS for ultrafast separations Anal. Chem. 96 (34), 13888 - 13896 10.1021/acs.analchem.4c01958 |
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