Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Direct evidence for a critical role of CD30 in the development of allergic asthma
Autor Polte, T.; Behrendt, A.K.; Hansen, G.;
Journal / Serie Journal of Allergy and Clinical Immunology
Erscheinungsjahr 2006
Department IMMU;
Band/Volume 118
Heft 4
Sprache englisch;
Keywords Asthma; costimulation; TH2 cells; CD30; immunotherapy
Abstract Background: CD30 is a costimulatory molecule belonging to the TNF receptor superfamily that is expressed on activated T and B cells. Several studies have demonstrated a positive correlation between expression of CD30 or increased levels of soluble CD30 and the development and severity of allergic diseases. However, thus far, the evidence for a role of CD30 in allergic diseases, such as asthma, is only indirect. Objective: The aim of the study was to directly investigate the role of CD30 in a murine asthma model. Methods: CD30-deficient (B6.129P2-Tnfrsf8(tm1Mak)/J) and wild-type (WT) mice were immunized to ovalbumin (OVA) to induce an asthma-like phenotype and compared in our murine asthma model. Moreover, CD30/CD30 ligand signaling was blocked in OVA-immunized WT animals by using mAbs against CD30 receptor and its ligand, CD153. Results: The absence of CD30 in OVA-immunized CD30-deficient mice resulted in significantly reduced airway inflammation, serum IgE levels, and T(H)2 cytokine levels. The same effect was observed when CD30/CD153 signaling was blocked in OVA-immunized WT animals with mAbs against CD30 or CD30 ligand. Conclusion: Our results directly demonstrate that CD30/CD153 interaction plays an important role in the induction of TH2 cell-mediated allergic asthma. Clinical implications: These findings provide evidence for a role of the costimulatory molecule CD30 in allergic asthma
ID 2919
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2919
Polte, T., Behrendt, A.K., Hansen, G. (2006):
Direct evidence for a critical role of CD30 in the development of allergic asthma
J. Allergy Clin. Immunol. 118 (4), 942 - 948