Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1111/liv.15842
Lizenz creative commons licence
Titel (primär) Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants
Autor Rau, F.; Elsner, C.; Meister, T.L.; Gömer, A.; Kallies, R.; Dittmer, U.; Steinmann, E.; Todt, D.
Quelle Liver International
Erscheinungsjahr 2024
Department AME
Band/Volume 44
Heft 3
Seite von 637
Seite bis 643
Sprache englisch
Topic T7 Bioeconomy
Keywords hepatitis E virus; surveillance; treatment plants; wastewater; wastewater-based epidemiology
Abstract Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North-Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT-PCR. Using high-throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome.
dauerhafte UFZ-Verlinkung
Rau, F., Elsner, C., Meister, T.L., Gömer, A., Kallies, R., Dittmer, U., Steinmann, E., Todt, D. (2024):
Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants
Liver Int. 44 (3), 637 - 643 10.1111/liv.15842