Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.neulet.2005.10.039
Titel (primär) COX-2 expression in the guinea pig cochlea is partly altered by moderate sound exposure
Autor Heinrich, U.R.; Brieger, J.; Selivanova, O.; Feltens, R.; Eimermacher, A.; Schäfer, D.; Mann, W.J.
Quelle Neuroscience Letters
Erscheinungsjahr 2006
Department IMMU
Band/Volume 394
Heft 2
Seite von 121
Seite bis 126
Sprache englisch
Keywords COX-2; cochlea; guinea pig; noise-exposure; sound conditioning
Abstract The cyclooxygenase-2 isoform (COX-2) was found recently to be constitutively expressed in the guinea pig inner ear. To gain knowledge about its role in sound perception, alterations in the COX-2 level of moderate noise-stimulated cochleae were determined. Staining intensities were quantified in different regions using an immunohistochemical staining procedure and computer-assisted system. After 70 dB and 90 dB noise exposure for I It at 8000 Hz, COX-2 downregulation was observed in the organ of Corti, which was most prominent in Deiters' cells near Hensen cells and outer hair cells. In pillar cells, COX-2 levels were only slightly reduced after 70 dB but strongly diminished after 90 dB exposure. In Hensen cells, COX-2 was downregulated after 70 dB stimulation, revealing a decreasing COX-2 content from the third to the first turn of the cochlea and a homogeneously reduced enzyme expression in all three turns after 90 dB. The COX-2 content in inner hair cells was nearly identical to unexposed cochleae after 70 dB exposure but significantly reduced after 90 dB stimulation. In spiral ganglion cells, stria vascularis, spiral ligament and limbus, COX-2 expression was unchanged after 70 dB and 90 dB. We suggest that alterations in COX-2 expression might contribute to diminished sensitivity at the cochlea after noise exposure to reduce subsequent noise distress, termed sound conditioning.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2689
Heinrich, U.R., Brieger, J., Selivanova, O., Feltens, R., Eimermacher, A., Schäfer, D., Mann, W.J. (2006):
COX-2 expression in the guinea pig cochlea is partly altered by moderate sound exposure
Neurosci. Lett. 394 (2), 121 - 126 10.1016/j.neulet.2005.10.039