Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1038/s42255-022-00703-9 |
Lizenz  |
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| Titel (primär) | Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity |
| Autor | Kempf, E.; Landgraf, K.; Stein, R.; Hanschkow, M.; Hilbert, A.; Abou Jamra, R.; Boczki, P.; Herberth, G.
; Kühnapfel, A.; Tseng, Y.-H.; Stäubert, C.; Schöneberg, T.; Kühnen, P.; Rayner, N.W.; Zeggini, E.; Kiess, W.; Blüher, M.; Körner, A. |
| Quelle | Nature Metabolism |
| Erscheinungsjahr | 2022 |
| Department | IMMU |
| Band/Volume | 4 |
| Seite von | 1697 |
| Seite bis | 1712 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Keywords | Gene regulation; Metabolic syndrome; Metabolism; Obesity; Paediatric research |
| Abstract | Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places ASIP under control of the ubiquitously active itchy E3 ubiquitin protein ligase promoter, driving the generation of ASIP in patient-derived native and induced pluripotent stem cells for all germ layers and hypothalamic-like neurons. The patient’s phenotype of early-onset obesity, overgrowth, red hair and hyperinsulinemia is concordant with that of mutant mice ubiquitously expressing the homolog nonagouti. ASIP represses melanocyte-stimulating hormone-mediated activation as a melanocortin receptor antagonist, which might affect eating behavior, energy expenditure, adipocyte differentiation and pigmentation, as observed in the index patient. As the type of mutation escapes standard genetic screening algorithms, we rescreened the Leipzig Childhood Obesity cohort of 1,745 patients and identified four additional patients with the identical mutation, ectopic ASIP expression and a similar phenotype. Taken together, our data indicate that ubiquitous ectopic ASIP expression is likely a monogenic cause of human obesity. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25957 |
| Kempf, E., Landgraf, K., Stein, R., Hanschkow, M., Hilbert, A., Abou Jamra, R., Boczki, P., Herberth, G., Kühnapfel, A., Tseng, Y.-H., Stäubert, C., Schöneberg, T., Kühnen, P., Rayner, N.W., Zeggini, E., Kiess, W., Blüher, M., Körner, A. (2022): Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity Nat. Metab. 4 , 1697 - 1712 10.1038/s42255-022-00703-9 |
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