Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Active drug transport of immunosuppressants - New insights for pharmacokinetics and pharmacodynamics
Autor Christians, U.; Strom, T.; Zhang, Y.L.; Steudel, W.; Schmitz, V.; Trump, S.; Haschke, M.;
Journal / Serie Therapeutic Drug Monitoring
Erscheinungsjahr 2006
Department IMMU;
Band/Volume 28
Heft 1
Sprache englisch;
Abstract

Immunosuppressants have a narrow therapeutic index, and pharmacokinetic variability negatively affects long-term outcome of transplantation. Recently, it has become clear that active transport is a major determinant of the inter-and intraindividual variability of the pharmacokinetics and pharmacodynamics of immunosuppressants. Active transport plays a key role in (1) the poor correlation between oral doses and systemic exposure of cyclosporine, tacrolimus, sirolimus, and everolimus, (2) tissue distribution including distribution into lymphocytes, (3) hepatic and intestinal metabolism, (4) the pharmacokinetic variability of immunosuppressants after oral dosing, (5) drug-drug interactions, (6) disease-drug interactions, and (7) age, gender, and ethnicity-based differences in pharmacokinetics of immunosuppressants. Those new insights may significantly improve patient management and long-term Outcome not only by reducing pharmacokinetic variability and avoidance of drug-drug interactions but also by identification of sensitive patient populations. They will also significantly impact preclinical and clinical development strategies of new immunosuppressants.

ID 2566
dauerhafte UFZ-Verlinkung http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2566
Christians, U., Strom, T., Zhang, Y.L., Steudel, W., Schmitz, V., Trump, S., Haschke, M. (2006):
Active drug transport of immunosuppressants - New insights for pharmacokinetics and pharmacodynamics
Ther. Drug Monit. 28 (1), 39 - 44