Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Creative Commons Lizenz creative commons licence
Titel (primär) The role of GPR15 function in blood and vasculature
Autor Bauer, M.;
Journal / Serie International Journal of Molecular Sciences
Erscheinungsjahr 2021
Department IMMU;
Band/Volume 22
Heft 19
Sprache englisch;
Keywords GPR15; C10orf99; thrombomodulin; lymphocyte; blood; endothelial cell; vasculature
Abstract Since the first prominent description of the orphan G protein-coupled receptor 15 (GPR15) on lymphocytes as a co-receptor for the human immunodeficiency virus (HIV) type 1 and 2 and the first report about the GPR15-triggered cytoprotective effect on vascular endothelial cells by recombinant human thrombomodulin, several decades passed before the GPR15 has been recently deorphanized. Because of new findings on GPR15, this review will summarize the consequences of GPR15 signaling considering the variety of GPR15-expressing cell types and of GPR15 ligands, with a focus on blood and vasculature.
ID 25205
dauerhafte UFZ-Verlinkung
Bauer, M. (2021):
The role of GPR15 function in blood and vasculature
Int. J. Mol. Sci. 22 (19), art. 10824