Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1007/s00253-023-12406-6
Lizenz creative commons licence
Titel (primär) Toward the future of OECD/ISO biodegradability testing-new approaches and developments
Autor Strotmann, U.; Thouand, G.; Pagga, U.; Gartiser, S.; Heipieper, H.J. ORCID logo
Quelle Applied Microbiology and Biotechnology
Erscheinungsjahr 2023
Department UBT
Band/Volume 107
Heft 7-8
Seite von 2073
Seite bis 2095
Sprache englisch
Topic T7 Bioeconomy
Keywords Chemicals; Biodegradability; Standardized tests; OECD; ISO; Combined test systems; Biodegradation adaption potential (BAP); Inocula; Environmental biotechnology
Abstract In the past decades, industrial and scientific communities have developed a complex standardized system (e.g., OECD, ISO, CEN) to evaluate the biodegradability of chemical substances. This system includes for OECD three levels of testing (ready and inherent biodegradability tests, simulation tests). It was adopted by many countries and is completely integrated into European legislation (registration, evaluation, authorization, and restriction of chemicals, REACH). Nevertheless, the different tests have certain deficiencies, and the question arises of how accurately these tests display the situation in the real environment and how the results can be used for predictions. This review will focus on the technical advantages and weaknesses of current tests concerning the technical setup, the inoculum characterization, and its biodegradation potential as well as the use of adequate reference compounds. A special focus of the article will be on combined test systems offering enhanced possibilities to predict biodegradation. The properties of microbial inocula are critically discussed, and a new concept concerning the biodegradation adaptation potential (BAP) of inocula is proposed. Furthermore, a probability model and different in silico QSAR (quantitative structure-activity relationships) models to predict biodegradation from chemical structures are reviewed. Another focus lies on the biodegradation of difficult single compounds and mixtures of chemicals like UVCBs (unknown or variable composition, complex reaction products, or biological materials) which will be an important challenge for the forthcoming decades.
dauerhafte UFZ-Verlinkung
Strotmann, U., Thouand, G., Pagga, U., Gartiser, S., Heipieper, H.J. (2023):
Toward the future of OECD/ISO biodegradability testing-new approaches and developments
Appl. Microbiol. Biotechnol. 107 (7-8), 2073 - 2095 10.1007/s00253-023-12406-6