Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1002/etc.5181
Lizenz creative commons licence
Titel (primär) Sources and fate of the antiandrogenic fluorescent dye 4-methyl-7-diethylaminocoumarin in small river systems
Autor Muschket, M.; Brack, W.; Inostroza, N.G.; Beckers, L.-M.; Schulze, T. ORCID logo ; Krauss, M. ORCID logo
Quelle Environmental Toxicology and Chemistry
Erscheinungsjahr 2021
Department WANA; ANA
Band/Volume 40
Heft 11
Seite von 3078
Seite bis 3091
Sprache englisch
Topic T9 Healthy Planet
Keywords bioaccumulation; endocrine disrupting compounds; environmental fate; environmental partitioning; equilibrium partitioning theory
Abstract Recently, the potent antiandrogen 4-methyl-7-diethylaminocoumarin (C47), and its potential transformation products 4-methyl-7-ethylaminocoumarin (C47T1) and 4-methyl-7-aminocoumarin (C47T2) were identified as novel environmental contaminants. We assessed for the first time the sources, distribution and fate of these compounds in aquatic systems using the Holtemme river (Saxony-Anhalt, Germany), which is a hotspot for these contaminants. To this end, wastewater treatment plant influent and effluent samples, surface water samples over three years and the longitudinal profiles in water, sediment and gammarids were analyzed. From the longitudinal profile of the river stretch, the wastewater treatment plant (WWTP) of Silstedt was identified as the sole point source for these compounds in the River Holtemme, and exposure concentrations in the low µg/L range could be recorded continuously over three years. The analysis of WWTP influent and effluent showed a transformation of about half of the C47 into C47T1 and C47T2, but no complete removal. A further attenuation of the three coumarins after discharge into the river could be largely attributed to dilution, while transformation was only around 20%, thus suggesting a significant persistence in aquatic systems. Experimentally derived partitioning coefficients between water and sediment organic carbon (KOC) exceeded those predicted using the OPERA QSAR tools and poly-parameter linear free energy relationships by up to 93-fold, suggesting cation binding as a significant factor for their sorption behavior. Near-equilibrium conditions between water and sediment were not observed close to the emitting WWTP but further downstream in the river. Experimental and predicted bioaccumulation factors for gammarids were closely matching and the concentrations in field-sampled gammarids were close to steady-state with exposure concentrations in the water phase of the river.
dauerhafte UFZ-Verlinkung
Muschket, M., Brack, W., Inostroza, N.G., Beckers, L.-M., Schulze, T., Krauss, M. (2021):
Sources and fate of the antiandrogenic fluorescent dye 4-methyl-7-diethylaminocoumarin in small river systems
Environ. Toxicol. Chem. 40 (11), 3078 - 3091 10.1002/etc.5181