Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.3390/life10120322
Lizenz creative commons licence
Titel (primär) Small but smart: On the diverse role of small proteins in the regulation of cyanobacterial metabolism
Autor Brandenburg, F.; Klähn, S.
Quelle Life
Erscheinungsjahr 2020
Department SOMA
Band/Volume 10
Heft 12
Seite von art. 322
Sprache englisch
Keywords small proteins; metabolic regulation; biotechnology
UFZ Querschnittsthemen MIKAT;
Abstract Over the past few decades, bioengineered cyanobacteria have become a major focus of research for the production of energy carriers and high value chemical compounds. Besides improvements in cultivation routines and reactor technology, the integral understanding of the regulation of metabolic fluxes is the key to designing production strains that are able to compete with established industrial processes. In cyanobacteria, many enzymes and metabolic pathways are regulated differently compared to other bacteria. For instance, while glutamine synthetase in proteobacteria is mainly regulated by covalent enzyme modifications, the same enzyme in cyanobacteria is controlled by the interaction with unique small proteins. Other prominent examples, such as the small protein CP12 which controls the Calvin–Benson cycle, indicate that the regulation of enzymes and/or pathways via the attachment of small proteins might be a widespread mechanism in cyanobacteria. Accordingly, this review highlights the diverse role of small proteins in the control of cyanobacterial metabolism, focusing on well-studied examples as well as those most recently described. Moreover, it will discuss their potential to implement metabolic engineering strategies in order to make cyanobacteria more definable for biotechnological applications.
dauerhafte UFZ-Verlinkung
Brandenburg, F., Klähn, S. (2020):
Small but smart: On the diverse role of small proteins in the regulation of cyanobacterial metabolism
Life 10 (12), art. 322 10.3390/life10120322