Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota
Autor Fischer, F.; Romero, R.; Hellhund, A.; Linne, U.; Bertrams, W.; Pinkenburg, O.; Eldin, H.S.; Binder, K.; Jacob, R.; Walker, A.; Stecher, B.; Basic, M.; Luu, M.; Mahdavi, R.; Heintz-Buschart, A.; Visekruna, A.; Steinhoff, U.;
Journal / Serie Gut Microbes
Erscheinungsjahr 2020
Department BOOEK;
Band/Volume 12
Heft 1
Sprache englisch;
POF III (gesamt) T11;
Supplements https://www.tandfonline.com/doi/suppl/10.1080/19490976.2020.1829962/suppl_file/kgmi_a_1829962_sm8476.zip
Keywords Cellulose; insoluble fiber; microbiota maturation; microbial diversity; bile acids; mucosal homeostasis; inflammation; Alistipes; Reg3γ; IL-22
Abstract

Although it is generally accepted that dietary fiber is health promoting, the underlying immunological and molecular mechanisms are not well defined, especially with respect to cellulose, the most ubiquitous dietary fiber. Here, the impact of dietary cellulose on intestinal microbiota, immune responses and gene expression in health and disease was examined. Lack of dietary cellulose disrupted the age-related diversification of the intestinal microbiota, which subsequently remained in an immature state. Interestingly, one of the most affected microbial genera was Alistipes which is equipped with enzymes to degrade cellulose. Absence of cellulose changed the microbial metabolome, skewed intestinal immune responses toward inflammation, altered the gene expression of intestinal epithelial cells and mice showed increased sensitivity to colitis induction. In contrast, mice with a defined microbiota including A. finegoldii showed enhanced colonic expression of intestinal IL-22 and Reg3γ restoring intestinal barrier function. This study supports the epidemiological observations and adds a causal explanation for the health promoting effects of the most common biopolymer on earth.

ID 23880
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23880
Fischer, F., Romero, R., Hellhund, A., Linne, U., Bertrams, W., Pinkenburg, O., Eldin, H.S., Binder, K., Jacob, R., Walker, A., Stecher, B., Basic, M., Luu, M., Mahdavi, R., Heintz-Buschart, A., Visekruna, A., Steinhoff, U. (2020):
Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota
Gut Microbes 12 (1), e1829962