Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Combined effects of mycotoxin mixtures on human T cell function
Autor Tammer, B.; Lehmann, I.; Nieber, K.; Altenburger, R.;
Journal / Serie Toxicology Letters
Erscheinungsjahr 2007
Department BIOTOX; IMMU;
Band/Volume 170
Heft 2
Sprache englisch;
Keywords Combined effect; Concentration addition; Response addition; Mycotoxin; Mixture toxicity prediction
Abstract Combined effects of mycotoxin mixtures are of major concern due to of the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon to functional activity of immune cells. Therefore, a well established model for immunotoxic studies using stimulated human peripheral blood mononuclear cells (PBMC) was applied. To predict the combined effect of the mixture the concepts of concentration addition and response addition were used. Comparable to the individual mycotoxins the mixture suppressed the cytokine production in a concentration dependent manner. The mixture effect was stronger than the effects caused by the toxins applied singly. The response addition concept described the mixture data within their experimental uncertainty. The in vitro test model presented here was practical to detect and quantify combined effects. Low and weak effect concentrations of mycotoxins may cause strong inhibitory effects on immune functions when occurring together. The experimental design using the concept of concentration addition and response addition was suitable for predicting the combined effects of mycotoxin mixtures in functional in vitro assays.
ID 2360
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2360
Tammer, B., Lehmann, I., Nieber, K., Altenburger, R. (2007):
Combined effects of mycotoxin mixtures on human T cell function
Toxicol. Lett. 170 (2), 124 - 133