Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1021/acs.est.0c02235
Volltext Akzeptiertes Manuskript
Titel (primär) Assessing the mixture effects in in vitro bioassays of chemicals occurring in small agricultural streams during rain events
Autor Neale, P.A.; Braun, G.; Brack, W.; Carmona, E. ORCID logo ; Gunold, R.; König, M.; Krauss, M. ORCID logo ; Liebmann, L.; Liess, M.; Link, M.; Schäfer, R.B.; Schlichting, R.; Schreiner, V.C.; Schulze, T. ORCID logo ; Vormeier, P.; Weisner, O.; Escher, B.I.
Quelle Environmental Science & Technology
Erscheinungsjahr 2020
Band/Volume 54
Heft 13
Seite von 8280
Seite bis 8290
Sprache englisch
Abstract Rain events may impact the chemical pollution burden in rivers. Forty-four small streams in Germany were profiled during several rain events for the presence of 395 chemicals and five types of mixture effects in in vitro bioassays (cytotoxicity; activation of the estrogen, aryl hydrocarbon, and peroxisome proliferator-activated receptors; and oxidative stress response). While these streams were selected to cover a wide range of agricultural impacts, in addition to the expected pesticides, wastewater-derived chemicals and chemicals typical for street runoff were detected. The unexpectedly high estrogenic effects in many samples indicated the impact by wastewater or overflow of combined sewer systems. The 128 water samples exhibited a high diversity of chemical and effect patterns, even for different rain events at the same site. The detected 290 chemicals explained only a small fraction (<8%) of the measured effects. The experimental effects of the designed mixtures of detected chemicals that were expected to dominate the mixture effects of detected chemicals were consistent with predictions for concentration addition within a factor of two for 94% of the mixtures. Overall, the burden of chemicals and effects was much higher than that previously detected in surface water during dry weather, with the effects often exceeding proposed effect-based trigger values.
dauerhafte UFZ-Verlinkung
Neale, P.A., Braun, G., Brack, W., Carmona, E., Gunold, R., König, M., Krauss, M., Liebmann, L., Liess, M., Link, M., Schäfer, R.B., Schlichting, R., Schreiner, V.C., Schulze, T., Vormeier, P., Weisner, O., Escher, B.I. (2020):
Assessing the mixture effects in in vitro bioassays of chemicals occurring in small agricultural streams during rain events
Environ. Sci. Technol. 54 (13), 8280 - 8290 10.1021/acs.est.0c02235